ArticleScience advances2022
Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.bioRxiv : the preprint server for biology · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- CRAC channels as targets for immunotherapy.Current opinion in immunology · 2026Review
- The role of T cells in influenza infection and vaccination.Virologica Sinica · 2026Review
- CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity.Science immunology · 2025Article
- STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TNature immunology · 2025Article
- Polymorphism-driven immune disruptions in Kawasaki disease across populations: decoding the role of T and B-cells.Frontiers in immunology · 2025Review
- IFN-γ-producing TScience translational medicine · 2024Article
- Channel plan: control of adaptive immune responses by pannexins.Trends in immunology · 2024Review
- House dust mite allergens, store-operated CaThe Journal of physiology · 2024Review
- Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Synthetic Biology Meets CaCells · 2024Review
- Anti-Inflammatory Effects of Alphitolic Acid Isolated fromInternational journal of molecular sciences · 2023Article
- Inhibition of γ-glutamyl transferase suppresses airway hyperresponsiveness and airway inflammation in a mouse model of steroid resistant asthma exacerbation.Frontiers in immunology · 2023Article
- Interactions between calcium regulatory pathways and mechanosensitive channels in airways.Expert review of respiratory medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Yin-Hu WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-3637-8852
Lucile NoyerDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-1369-684X
Sascha KahlfussDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-8813-1061
Dimitrius RaphaelDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-1064-3010
Anthony Y TaoDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-0978-2769
Ulrike KaufmannDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-4317-5794
Jingjie ZhuDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Marisa Mitchell-FlackDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-3192-0865
Ikjot SidhuDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-1470-6421
Fang ZhouDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-5542-2994
Martin VaethDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-8974-7052
Paul G ThomasSt. Jude's Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7955-0256
Sean P SaundersDivision of Pulmonary, Critical Care and Sleep Medicine, Departments of Medicine and Cell Biology, New York University Grossman School of Medicine, NY 10016, USA.
Kenneth StaudermanCalciMedica Inc., La Jolla, CA 92037, USA.ORCID 0000-0002-8090-4549
Maria A Curotto de LafailleDivision of Pulmonary, Critical Care and Sleep Medicine, Departments of Medicine and Cell Biology, New York University Grossman School of Medicine, NY 10016, USA.ORCID 0000-0002-3510-3777
Stefan FeskeDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
New York University · USCalciMedica (United States) · USSt. Jude Children's Research Hospital · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MDYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9MCRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6MTraining Program in Immunology and Inflammation.T32AI100853 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2012 to 2026
$4.5MCellular and molecular mechanisms of IgE cell memory in allergic responsesR01AI130343 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CUROTTO DE LAFAILLE, MARIA A, LAFAILLE, JUAN · 2017 to 2021
$2.9MRegulation of Follicular T cell Responses in the Lung by Ion ChannelsR01AI130143 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2017 to 2021
$2.4MA protective role for gamma delta T cells in respiratory infectionR01AI121832 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI THOMAS, PAUL G. · 2016 to 2020
$2.2MThe Origin and Memory of Human IgE ResponsesR21AI133076 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CUROTTO DE LAFAILLE, MARIA A · 2017 to 2018
$466kNCI NIH HHS P30 CA016087NIAID NIH HHS R01 AI097302NIAID NIH HHS R01 AI121832NIAID NIH HHS R01 AI130143NIAID NIH HHS R01 AI130343NIAID NIH HHS R21 AI133076NIAID NIH HHS T32 AI100853NIAID NIH HHS U01 AI150747
Abstract
T cell activation and function depend on Ca
Indexed as
Calcium ChannelsInfluenza A virusAllergensAnimalsCalciumCalcium SignalingCytokinesE2F Transcription FactorsInflammationMiceORAI1 ProteinStromal Interaction Molecule 1Transcription FactorsTumor Suppressor Protein p53AllergensCalciumCalcium ChannelsCytokinesE2F Transcription FactorsORAI1 ProteinOrai1 protein, mouseStromal Interaction Molecule 1Transcription FactorsTumor Suppressor Protein p53
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.