ArticlePLoS genetics2022
Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 34 citations in OpenAlex.
- A bitter receptor links chemical detection to adaptive foraging avoidance in fire ants.Pest management science · 2026Article
- Host selection in Megabruchidius dorsalis under storage conditions: investigating the role of visual, gustatory and olfactory cues in feeding and reproductive behaviors.Pest management science · 2026Article
- Plant strategies against herbivorous insects.Journal of integrative plant biology · 2026Review
- A Comprehensive Molecular and Evolutionary Characterization of Chemosensory-Related Genes inAnimals : an open access journal from MDPI · 2026Article
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- The lepidopteran analyst: how caterpillars, moths and butterflies encode taste identity and valence.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Identification of candidate chemosensory receptors based on transcriptome analysis in the monophagous insect Protegira songi (Lepidoptera, Noctuidae).BMC genomics · 2026Article
- Transcriptome Analysis of the Brain and Gnathal Ganglion Reveals Feeding-Mediated Genes inBiomolecules · 2026Article
- Transcriptomic analysis of Camellia japonica to scale insects infestation and functional characterization of pectin methylesterase gene CjPME28 and polygalacturonase gene CjPG1.Plant cell reports · 2025Article
- Color-dependent defense mechanisms of Quinoa (Chenopodium quinoa Willd.) against Spodoptera exigua: metabolomic and transcriptomic insights.BMC plant biology · 2025Article
- Where do all the pests go? Understanding the genomic mechanisms of crop pest dynamics during the off-season.Current opinion in insect science · 2025Review
- HarmGR13 mediates myo-inositol taste perception in Helicoverpa armigera larvae.PLoS genetics · 2025Article
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- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Molecular Functions and Physiological Roles of Gustatory Receptors of the SilkwormInternational journal of molecular sciences · 2024Review
- The larva and adult ofeLife · 2024Article
- Research on the Effect of Oriental Fruit Moth Feeding on the Quality Degradation of Chestnut Rose Juice Based on Metabolomics.Molecules (Basel, Switzerland) · 2023Article
- Natural Coumarin Shows Toxicity toInternational journal of molecular sciences · 2023Article
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- Genetic Diversity of a Heat Activated Channel-TRPV1 in Two Desert Gerbil Species with Different Heat Sensitivity.International journal of molecular sciences · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many plant secondary substances are feeding deterrents for insects and play a key role in the selection of host plants. The taste sensilla of phytophagous insects contain gustatory sensory neurons sensitive to deterrents but the molecular basis of deterrent chemoreception remains unknown. We investigated the function of Gr180, the most highly expressed bitter gustatory receptor in the maxillary galea of Helicoverpa armigera larvae. Functional analyses using the Xenopus oocyte expression system and two-electrode voltage clamp revealed that the oocytes expressing Gr180 responded to coumarin. Tip recording results showed that the medial sensilla styloconica of the maxilla of fifth instar larvae exhibited electrophysiological responses to coumarin. Two-choice feeding bioassays confirmed that coumarin inhibited larval feeding. A homozygous mutant strain of H. armigera with truncated Gr180 proteins (Gr180-/-) was established using the CRISPR-Cas9 system. The responses of the medial sensilla styloconica in Gr180-/- to coumarin were almost abolished, and the responses to sinigrin and strychnine were also significantly decreased. Knockout of Gr180 alleviated the feeding deterrent effects of coumarin, sinigrin, and strychnine. Thus, we conclude that Gr180 is a receptor responding to coumarin,and also participates in sensing sinigrin and strychnine. These results enhance our understanding of the gustatory sensing mechanisms of phytophagous insects to deterrents.
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