Evidence map›Paper›PMID 36206160›Full record

ReviewBiological research for nursing2023

The Cancer Genomic Integration Model for Symptom Science (CGIMSS): A Biopsychosocial Framework.

Susan C Grayson, Meredith H Cummings, Susan Wesmiller, Catherine Bender

Registry-linked trialAbstract readReview
In one paragraph

Review in Biological research for nursing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07481903 (Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07481903 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors

TypeinterventionalSponsorFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineRan2026 to 2028Enrolled228ConditionsPsychoneurological Symptom Cluster(Pain, Insomnia, Anxiety, Fatigue, Depression, Subjective Cognitive Decline), Pain, Insomnia, AnxietyArmselectroacupuncture, sham electroacupuncture
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Psychoneurological symptom cluster trajectories in individuals treated for early-stage breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susan C GraysonSchool of Nursing, 6614University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1893-603X
Meredith H CummingsSchool of Nursing, 6614University of Pittsburgh, Pittsburgh, PA, USA.
Susan WesmillerSchool of Nursing, 6614University of Pittsburgh, Pittsburgh, PA, USA.
Catherine BenderSchool of Nursing, 6614University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Targeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5M
NINR NIH HHS T32 NR009759
6 · The paper itself

Abstract

Current nursing research has characterized symptom clusters and trajectories in individuals with breast cancer. The existing literature describes the relationship between symptoms and biological variables and the potential moderating effects of individual and social factors. The genomic profiling of breast cancer has also been an area of much recent research. Emerging evidence indicates that incorporating cancer genomics into symptom science research can aid in the prognostication of symptoms and elucidate targets for symptom management interventions. The aim of this paper is to outline a model to integrate cancer genomics into symptom science research, illustrated using breast cancer and psychoneurological (PN) symptoms as an example. We present a review of the current literature surrounding breast cancer genomics (specifically cancer genomic instability) and the biological underpinnings of the PN symptom cluster. Advances in both of these areas indicate that inflammation may serve as the bridge between cancer genomics and the PN symptom cluster. We also outline how the integration of cancer genomics into symptom science research synergizes with current research of individual and social factors in relation to symptoms. This model aims to provide a framework to guide future biopsychosocial symptom science research that can elucidate new predictive methods and new targets for intervention.

Indexed as

Breast NeoplasmsNursing ResearchFemaleGenomicsHumansSyndromebreast cancercancer genomicssymptom clusterssymptom science

Identifiers

PMID36206160
PMCPMC10236443

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.