Evidence map›Paper›PMID 36205782›Full record

ArticlePflugers Archiv : European journal of physiology2023

Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels.

JinHeng Lin, Sean M Gettings, Khaoula Talbi, Rainer Schreiber, Michael J Taggart, Matthias Preller, Karl Kunzelmann, Mike Althaus, Michael A Gray

Open access · hybridAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Epithelial NaComprehensive Physiology · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

JinHeng LinBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Sean M GettingsSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Khaoula TalbiPhysiological Institute, University of Regensburg, 93053, Regensburg, Germany.
Rainer SchreiberPhysiological Institute, University of Regensburg, 93053, Regensburg, Germany.
Michael J TaggartBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Matthias PrellerDepartment of Natural Sciences/Institute for Functional Gene Analytics, Structural Biology Group, Bonn-Rhein-Sieg University of Applied Sciences, 53359, Rheinbach, Germany.
Karl KunzelmannPhysiological Institute, University of Regensburg, 93053, Regensburg, Germany.
Mike AlthausSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Michael A GrayBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. m.a.gray@newcastle.ac.uk.ORCID 0000-0002-6774-6283
Newcastle University · GBUniversity of Regensburg · DEHochschule Bonn-Rhein-Sieg · DEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorEpithelial Sodium ChannelsBenzoatesCationsGlycineHumansHydrazinesMolecular Docking SimulationThiazolidines3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinoneBenzoatesCationsCystic Fibrosis Transmembrane Conductance RegulatorEpithelial Sodium ChannelsGlycineHydrazinesN-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazideThiazolidinesCFTR inhibitorsENaCIn silico modellingOff-target effectsOrai1Store-operated calcium entry

Identifiers

PMID36205782
PMCPMC9849171
OpenAlexW4303199205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.