Evidence map›Paper›PMID 36205763›Full record

ReviewApplied microbiology and biotechnology2022

Halomonas spp., as chassis for low-cost production of chemicals.

Guo-Qiang Chen, Xu Zhang, Xu Liu, Weiran Huang, Zhengwei Xie, Jing Han, Tong Xu, Ruchira Mitra, Cheng Zhou, Jing Zhang and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Decoding metabolic trade-offs inSynthetic and systems biotechnology · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guo-Qiang ChenMOE Key Laboratory for Industrial Biocatalysts, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China. chengq@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-7226-1782
Xu ZhangMOE Key Laboratory for Industrial Biocatalysts, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
Xu LiuPhaBuilder Biotechnol Co. Ltd. Shunyi District, Zhaoquan Ying, Beijing, 101309, China.
Weiran HuangPeking University International Cancer Institute, Peking University Health Science Center, Peking University, Haidian District, Beijing, 100191, China.
Zhengwei XiePeking University International Cancer Institute, Peking University Health Science Center, Peking University, Haidian District, Beijing, 100191, China.
Jing HanState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
Tong XuState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
Ruchira MitraState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
Cheng ZhouState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
Jing ZhangFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Tao ChenFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.

Funding

National Natural Science Foundation of China No. 21761132013National Natural Science Foundation of China No. 31870859National Natural Science Foundation of China No. 92068117the Ministry of Science and Technology of China 2018YFA0900200
6 · The paper itself

Abstract

Halomonas spp. are the well-studied platform organisms or chassis for next-generation industrial biotechnology (NGIB) due to their contamination-resistant nature combined with their fast growth property. Several Halomonas spp. have been studied regarding their genomic information and molecular engineering approaches. Halomonas spp., especially Halomonas bluephagenesis, have been engineered to produce various biopolyesters such as polyhydroxyalkanoates (PHA), proteins including surfactants and enzymes, small molecular compounds including amino acids and derivates, as well as organic acids. This paper reviews all the progress reported in the last 10 years regarding this robust microbial cell factory. KEY POINTS: • Halomonas spp. are robust chassis for low-cost production of chemicals • Genomic information of some Halomonas spp. has been revealed • Molecular tools and approaches for Halomonas spp. have been developed • Halomonas spp. are becoming more and more important for biotechnology.

Indexed as

HalomonasPolyhydroxyalkanoatesAmino AcidsBiotechnologyMetabolic EngineeringSurface-Active AgentsAmino AcidsPolyhydroxyalkanoatesSurface-Active AgentsEctoineHalomonasHalophileMetabolic engineeringMorphology engineeringPHAPHBPolyhydroxyalkanoatesSynthetic biology

Identifiers

PMID36205763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.