Evidence map›Paper›PMID 36205758›Full record

ArticleRheumatology international2023

Serum beta-2 microglobulin as a predictor of nephritis, disease activity, and damage score in systemic lupus erythematosus: a cross-sectional study.

Dalia Mohamed Gamal, Fatma Mohammed Badr, Sara Ibrahim Abd El Fattah Taha, Nouran M Moustafa, Mohammed Abd El Monem Teama

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Biomarkers for systemic lupus erythematosus: A scoping review.Immunity, inflammation and disease · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dalia Mohamed GamalInternal Medicine, Rheumatology and Immunology, Faculty of Medicine, 2 Staff Member Buildings of Ain Shams University, Ramsis Street, Abbassya Square, El Al Waili/El-Abaseya, Post No: 11517, Cairo, Egypt.ORCID 0000-0001-8460-4837
Fatma Mohammed BadrInternal Medicine, Rheumatology and Immunology, Faculty of Medicine, 2 Staff Member Buildings of Ain Shams University, Ramsis Street, Abbassya Square, El Al Waili/El-Abaseya, Post No: 11517, Cairo, Egypt.ORCID 0000-0002-8753-1466
Sara Ibrahim Abd El Fattah TahaClinical Pathology Department, Faculty of Medicine, Ain Shams University, Ramsis Street, Abbassya Square, Cairo, Egypt.ORCID 0000-0001-8224-8701
Nouran M MoustafaMedical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Ramsis Street, Abbassya Square, Cairo, Egypt.ORCID 0000-0002-3956-1484
Mohammed Abd El Monem TeamaInternal Medicine, Rheumatology and Immunology, Faculty of Medicine, 2 Staff Member Buildings of Ain Shams University, Ramsis Street, Abbassya Square, El Al Waili/El-Abaseya, Post No: 11517, Cairo, Egypt. mohteama2009@yahoo.com.ORCID 0000-0002-3945-198X
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A strong correlation between lupus nephritis (LN), disease activity, and serum beta 2-microglobulin (b2MG) was observed. The current study examines the correlation between serum b2MG and renal involvement, damage score, and disease activity in systemic lupus erythematosus (SLE) patients. One hundred SLE patients from Ain Shams University Hospital were enrolled and categorized into two groups. Group I had 40 patients with negative b2MG, while Group II had 60 patients with positive b2MG levels. Medical history, clinical examination, and assessing disease activity based on SLE disease activity index (SLEDAI-2 K), and damage score were recorded for all patients. Laboratory examinations, such as serum b2MG, complete blood count, blood urea nitrogen (BUN), serum creatinine, glomerular filtration rate (GFR), urine analysis, 24 h urinary protein excretion, Antinuclear antibodies (ANA), anti-dsDNA antibody, and serum complement (C3, C4). BUN, 24 h urinary protein, serum creatinine, active urinary sediment, SLEDAI score, and damage score were all elevated in group II compared to group I (p < 0.001). There is a positive correlation between serum b2MG and 24 h urinary protein, BUN, serum creatinine, disease activity, and damage score (p < 0.001), while it was negatively correlated with GFR, C3, and C4 (p < 0.001). Serum b2MG has proven to be a predictor of LN in SLE patients (Sensitivity 92.45%, Specificity 74.47%), also being a predictor of the activity of the disease as well as damage index (Sensitivity 96.67%, Specificity 85%) (Sensitivity 92.45%, Specificity 74.47%), respectively. Serum b2MG level can be used as a valuable predictor for LN, clinical disease activity, and damage score.

Indexed as

Lupus Erythematosus, SystemicLupus Nephritisbeta 2-MicroglobulinBiomarkersCreatinineCross-Sectional StudiesHumansbeta 2-MicroglobulinBiomarkersCreatinineBiomarkerDisease activityLupus nephritisPrognosisSerum b2microglobulin

Identifiers

PMID36205758
PMCPMC9898324
OpenAlexW4303411581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.