Evidence map›Paper›PMID 36205670›Full record

ArticleThe western journal of emergency medicine2022

More Accessible COVID-19 Treatment Through Monoclonal Antibody Infusion in the Emergency Department.

Sara W Heinert, Jonathan McCoy, Pamela Ohman Strickland, Renee Riggs, Robert Eisenstein

Open access · goldAbstract read
In one paragraph

Article in The western journal of emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sara W HeinertRutgers Robert Wood Johnson Medical School, Department of Emergency Medicine, New Brunswick, New Jersey.
Jonathan McCoyRutgers Robert Wood Johnson Medical School, Department of Emergency Medicine, New Brunswick, New Jersey.
Pamela Ohman StricklandRutgers School of Public Health, Department of Biostatistics and Epidemiology, Piscataway, New Jersey.
Renee RiggsRutgers Robert Wood Johnson Medical School, Department of Emergency Medicine, New Brunswick, New Jersey.
Robert EisensteinRutgers Robert Wood Johnson Medical School, Department of Emergency Medicine, New Brunswick, New Jersey.
Rutgers, The State University of New Jersey · USJohnson University · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI HELMUT ZARBL · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Institutional Career Development CoreKL2TR003018 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI CHAN, JOHN R., HALM, ETHAN A · 2019 to 2023
$3.0M
NCATS NIH HHS KL2 TR003018NCATS NIH HHS UL1 TR003017NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

introductionMonoclonal antibody (MAB) infusion is the first treatment to manage coronavirus 2019 (COVID-19) in an outpatient setting. Yet increased risk of severe COVID-19 illness may occur from inequities in social determinants of health including access to quality healthcare. Given the safety-net nature of emergency departments (ED), a model that puts them at the center of MAB infusion may better reach underserved patients than models that require physician referral and distribute MAB at outpatient infusion centers. We examined characteristics of two groups of patients who received MAB infusion in the Robert Wood Johnson University Hospital (RWJUH) ED in New Brunswick, New Jersey: 1) patients who tested positive for COVID-19 in the ED and received ED infusion; and 2) patients who tested positive elsewhere and were referred to the ED for infusion. The process for the latter group was similar to the more common national model of patients testing COVID-19 positive in the community and then being referred to an infusion center for MAB therapy.

methodsWe performed a cross-sectional retrospective health record review of all adult patients presenting to the ED from November 20, 2020-March 15, 2021 who received MAB infusion at RWJUH ED (N = 486). Patients were identified through the electronic health record system by an administrative query, with manual chart review for any additional characteristics not available through the query. We compared the two groups using chi-squared tests for categorical variables and t-tests for continuous variables.

resultsWe found higher proportions of Black (18% vs 6% P < 0.001, statistically significant), Hispanic (19% vs 11% P = 0.02), Medicaid (12% vs 9% P = 0.01), and uninsured (17% vs 8% P = 0.01) patients who tested positive for COVID-19 in their ED visit and then received MAB therapy during their visit than patients tested elsewhere in the community and referred to the ED for MAB therapy.

conclusionThese findings suggest that providing MAB infusion in the ED allows increased access for patients traditionally marginalized from the healthcare system, who may be at risk of longer disease duration and complications from COVID-19.

Indexed as

CoronavirusCoronavirus InfectionsCOVID-19 Drug TreatmentAdultAntibodies, MonoclonalCross-Sectional StudiesEmergency Service, HospitalHumansRetrospective StudiesAntibodies, Monoclonal

Identifiers

PMID36205670
PMCPMC9541995
OpenAlexW4296886983

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.