ArticleAmerican journal of human biology : the official journal of the Human Biology Council2022
Minimally invasive biomarkers in human and non-human primate evolutionary biology: Tools for understanding variation and adaptation.
Article in American journal of human biology : the official journal of the Human Biology Council, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Navigating Practical, Political, and Ethical Challenges of Long-Term Human Biology Field Research: The Shuar Health and Life History Project.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- An Adult Arrhythmia in a Child's Heart: A Case Report of Unexplained Atrial Fibrillation.Reports (MDPI) · 2025Article
- Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild.American journal of primatology · 2025Review
- Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations.Metabolites · 2025Review
- Circulating Epstein-Barr Virus Antibody Levels as a Biomarker of Socioecological Adversity in Amazonian Ecuador.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Wild bonobos experience unusually low bone resorption during early lactation relative to humans and other mammals.Evolutionary human sciences · 2025Article
- Oxidative Stress in Children and Adolescents: Insights Into Human Biology.American journal of human biology : the official journal of the Human Biology Council · 2025Review
- Linking energy availability, movement and sociality in a wild primate (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- A non-invasive measure of bone growth in mammals: Validating urinary CTX-I as a bone resorption marker through long-bone growth velocity in bonobos.Ecology and evolution · 2024Article
- How prenatal cortisol levels relate to grandmother-mother relationships among a cohort of Latina women.American journal of human biology : the official journal of the Human Biology Council · 2023Article
- Minimally invasive biomarkers in human and non-human primate evolutionary biology: Tools for understanding variation and adaptation.American journal of human biology : the official journal of the Human Biology Council · 2022Article
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5 authors.
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Abstract
backgroundThe use of minimally invasive biomarkers (MIBs - physiological biomarkers obtained from minimally invasive sample types) has expanded rapidly in science and medicine over the past several decades. The MIB approach is a methodological strength in the field of human and non-human primate evolutionary biology (HEB). Among humans and our closest relatives, MIBs provide unique opportunities to document phenotypic variation and to operationalize evolutionary hypotheses.
aimsThis paper overviews the use of MIBs in HEB. Our objectives are to (1) highlight key research topics which successfully implement MIBs, (2) identify promising yet under-investigated areas of MIB application, and (3) discuss current challenges in MIB research, with suggestions for advancing the field. DISCUSSION AND
conclusionsA range of MIBs are used to investigate focal topics in HEB, including energetics and life history variation/evolution, developmental plasticity, and social status and dominance relationships. Nonetheless, we identify gaps in existing MIB research on traits such as physical growth and gut function that are central to the field. Several challenges remain for HEB research using MIBs, including the need for additional biomarkers and methods of assessment, robust validations, and approaches that are standardized across labs and research groups. Importantly, researchers must provide better support for adaptation and fitness effects in hypothesis testing (e.g., by obtaining complementary measures of energy expenditure, demonstrating redundancy of function, and performing lifetime/longitudinal analyses). We point to continued progress in the use of MIBs in HEB to better understand the past, present, and future of humans and our closest primate relatives.
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