ArticleExperimental physiology2023
Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance.
Article in Experimental physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- The environmental exposome in heart failure risk and progression.Nature reviews. Cardiology · 2026Review
- Exploratory thresholds for ambient PMBMC public health · 2026Article
- Patency of arteriovenous fistulas in hemodialysis in French Guiana: influence of vascular flow, climate and clinical factors.BMC nephrology · 2026Article
- Increased Risk of Recurrent Ischemic Stroke in Male Patients Taking Medications for Benign Prostatic Hyperplasia.Life (Basel, Switzerland) · 2026Article
- Ambient Cold and Mortality in Pan-Arterial Diseases: A Nationwide Ecological Analysis of CDC WONDER Data.Vascular health and risk management · 2026Article
- Combined effects of apparent low temperature and PMFrontiers in public health · 2026Article
- Bioceramic arm garment does not increase diameter of brachial artery and blood flow-Compliance and biceps microcirculation in male recreational sports practitioners at rest: A single blinded randomized cross-over study.Journal of sport and health science · 2025Article
- Cardiovascular and Thermal Responses to Cold Exposure During Exercise in Iron-Deficient Anemic Individuals.Journal of functional morphology and kinesiology · 2025Article
- Individuals with persisting post-concussion symptoms with physiological subtype demonstrate altered cardiovascular and autonomic responses to face cooling.Experimental physiology · 2025Article
- Outdoor temperature as a confounder of blood pressure in randomized trials.The Science of the total environment · 2025Article
- Studying Erythromelalgia Using Doppler Flowmetry Perfusion Signals and Wavelet Analysis-An Exploratory Study.Biomedicines · 2023Article
- Cardiovascular and mood responses to an acute bout of cold water immersion.Journal of thermal biology · 2023Article
- Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance.Experimental physiology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NEW
findingsWhat is the central question of this study? Why does blood pressure increases during cold air exposure? Specifically, what is the contribution of skin and skeletal muscle vascular resistance during whole body versus isolated face cooling? What is the main finding and its importance? Whole-body cooling caused an increase in blood pressure through an increase in skeletal muscle and cutaneous vascular resistance. However, isolated mild face cooling caused an increase in blood pressure predominately via an increase in cutaneous vasoconstriction. ABSTRACT: The primary aim of this investigation was to determine the individual contribution of the cutaneous and skeletal muscle circulations to the cold-induced pressor response. To address this, we examined local vascular resistances in the cutaneous and skeletal muscle of the arm and leg. Thirty-four healthy individuals underwent three different protocols, whereby cold air to clamp skin temperature (27°C) was passed over (1) the whole-body, (2) the whole-body, but with the forearm pre-cooled to clamp cutaneous vascular resistance, and (3) the face. Cold exposure applied to the whole body or isolated to the face increased mean arterial pressure (all, P < 0.001) and total peripheral resistance (all, P < 0.047) compared to thermal neutral baseline. Whole-body cooling increased femoral (P < 0.005) and brachial artery resistance (P < 0.003) compared to thermoneutral baseline. Moreover, when the forearm was pre-cooled to remove the contribution of cutaneous resistance (P = 0.991), there was a further increase in lower arm vasoconstriction (P = 0.036) when whole-body cooling was superimposed. Face cooling also caused a reflex increase in lower arm cutaneous (P = 0.009) and brachial resistance (P = 0.050), yet there was no change in femoral resistance (P = 0.815) despite a reflex increase in leg cutaneous resistance (P = 0.010). Cold stress causes an increase in blood pressure through a change in total peripheral resistance that is largely due to cutaneous vasoconstriction with face cooling, but there is additional vasoconstriction in the skeletal muscle vasculature with whole-body cooling.
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Registered trials
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