ArticleBJPsych open2022
The contribution of general medical conditions to the non-fatal burden of mental disorders: register-based cohort study in Denmark.
Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A genome-wide association study of social trust in 33,882 Danish blood donors.Scientific reports · 2024Pooled it
- Dissecting pleiotropy between major depressive disorder and physical disease comorbidities.Nature genetics · 2026Article
- Research on comorbidity characteristics and patterns of hospitalized participants with schizophrenia in China.Frontiers in psychiatry · 2025Article
- Associations between physical diseases and subsequent mental disorders: a longitudinal study in a population-based cohort.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Educational differences in years lived with disability due to mental and substance use disorders: a cohort study using nationwide Norwegian and Danish registries.BMC public health · 2024Article
- Excess healthcare costs of mental disorders in children, adolescents and young adults in the Basque population registry adjusted for socioeconomic status and sex.Cost effectiveness and resource allocation : C/E · 2023Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundGeneral medical conditions (GMCs) often co-occur with mental and substance use disorders (MSDs).
aimsTo explore the contribution of GMCs to the burden of disease in people with MSDs, and investigate how this varied by age.
methodA population-based cohort of 6 988 507 persons living in Denmark during 2000-2015 followed for up to 16 years. Danish health registers were used to identify people with MSDs and GMCs. For each MSD, years lived with disability and health loss proportion (HeLP) were estimated for comorbid MSDs and GMCs, using a multiplicative model for disability weights.
resultsThose with any MSD lost the equivalent of 43% of healthy life (HeLP = 0.43, 95% CI 0.40-0.44) after including information on GMCs, which was an increase from 25% before including GMCs (HeLP = 0.25, 95% CI 0.23-0.27). Schizophrenia was associated with the highest burden of disease (HeLP = 0.77, 95% CI 0.68-0.85). However, within each disorder, the relative contribution of MSDs and GMCs varied. For example, in those diagnosed with schizophrenia, MSDs and GMCs accounted for 86% and 14% of the total health loss; in contrast, in those with anxiety disorders, the same proportions were 59% and 41%. In general, HeLP increased with age, and was mainly associated with increasing rates of pulmonary, musculoskeletal and circulatory diseases.
conclusionsIn those with mental disorders, the relative contribution of comorbid GMCs to the non-fatal burden of disease increases with age. GMCs contribute substantially to the non-fatal burden of disease in those with MSDs.
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