Evidence map›Paper›PMID 36204829›Full record

ReviewNeural regeneration research2023

MicroRNAs: protective regulators for neuron growth and development.

Zhi-Xuan Ma, Zhen Liu, Hui-Hui Xiong, Zong-Pu Zhou, Li-Si Ouyang, Fu-Kang Xie, Ya-Mei Tang, Zhong-Dao Wu, Ying Feng

Abstract readReview
In one paragraph

Review in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Ketamine and Evolving Neuroplasticity.Clinical drug investigation · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Role of miRNAs in Brain Development.MicroRNA (Shariqah, United Arab Emirates) · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. The laws and effects of terahertz wave interactions with neurons.Frontiers in bioengineering and biotechnology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhi-Xuan MaSchool of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.
Zhen LiuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Hui-Hui XiongZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Zong-Pu ZhouSchool of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.
Li-Si OuyangZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Fu-Kang XieZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Ya-Mei TangDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Zhong-Dao WuKey Laboratory of Tropical Disease Control, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Ying FengSchool of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) play an important regulatory role in neuronal growth and development. Different miRNAs target different genes to protect neurons in different ways, such as by avoiding apoptosis, preventing degeneration mediated by conditional mediators, preventing neuronal loss, weakening certain neurotoxic mechanisms, avoiding damage to neurons, and reducing inflammatory damage to them. The high expression of miRNAs in the brain has significantly facilitated their development as protective targets for therapy, including neuroprotection and neuronal recovery. miRNA is indispensable to the growth and development of neurons, and in turn, is beneficial for the development of the brain and checking the progression of various diseases of the nervous system. It can thus be used as an important therapeutic target for models of various diseases. This review provides an introduction to the protective effects of miRNA on neurons in case of different diseases or damage models, and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.

Indexed as

brain damagemiRNAneurodegenerative disordersneuronal apoptosisneuronal protection

Identifiers

PMID36204829
PMCPMC9700101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.