Evidence map›Paper›PMID 36204688›Full record

ArticleHemaSphere2022

Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood

Mattias Pilheden, Louise Ahlgren, Axel Hyrenius-Wittsten, Veronica Gonzalez-Pena, Helena Sturesson, Hanne Vibeke Hansen Marquart, Birgitte Lausen, Anders Castor, Cornelis Jan Pronk, Gisela Barbany and 13 more

Open access · goldAbstract read
In one paragraph

Article in HemaSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Infant Acute Lymphoblastic Leukemia-New Therapeutic Opportunities.International journal of molecular sciences · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 4 countries.

Mattias PilhedenDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Louise AhlgrenDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Axel Hyrenius-WittstenDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Veronica Gonzalez-PenaDivision of Pediatric Hematology/Oncology, Stanford University, School of Medicine, Stanford, CA, USA.
Helena SturessonDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Hanne Vibeke Hansen MarquartDepartment of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
Birgitte LausenDepartment of Paediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Denmark.
Anders CastorChildhood Cancer Center, Skane University Hospital, Lund, Sweden.
Cornelis Jan PronkChildhood Cancer Center, Skane University Hospital, Lund, Sweden.
Gisela BarbanyDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Katja Pokrovskaja TammDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Linda FogelstrandDepartment of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Olli LohiTampere Center for Child, Adolescent and Maternal Health Research and Tays Cancer Center, Tampere University and Tampere University Hospital, Tampere, Finland.
Ulrika Norén-NyströmDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Johanna AsklinSAGA Diagnostics, Lund, Sweden.
Yilun ChenSAGA Diagnostics, Lund, Sweden.
Guangchun SongDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Michael WalshDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jing MaDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lao H SaalSAGA Diagnostics, Lund, Sweden.
Charles GawadDivision of Pediatric Hematology/Oncology, Stanford University, School of Medicine, Stanford, CA, USA.
Anna K Hagström-AnderssonDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Lund University · SEKarolinska Institutet · SEStanford University · USRigshospitalet · DKSkåne University Hospital · SESt. Jude Children's Research Hospital · USTampere University · FIUniversity of Gothenburg · SE

Funding

Creating a Catalog of Cancer Clonotype Drug Sensitivities with Single-CellGenome SequencingDP2CA239145 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GAWAD, CHARLES · 2018 to 2018
$2.3M
NCI NIH HHS DP2 CA239145
6 · The paper itself

Abstract

Infant acute lymphoblastic leukemia (ALL) with

Identifiers

PMID36204688
PMCPMC9529062
OpenAlexW4298111185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.