ArticleMediators of inflammation2022
Association of Red Cell Distribution Width-to-Platelet Ratio and Mortality in Patients with Sepsis.
Article in Mediators of inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 24 citations in OpenAlex.
- Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease.BMC cardiovascular disorders · 2026Article
- Association between red blood cell distribution width-platelet ratio and mortality in patients with sepsis-induced coagulopathy from the MIMIC-IV database: a retrospective cohort study.BMC infectious diseases · 2026Article
- Article
- The prognostic value of red cell distribution width-to-albumin ratio for 28-day mortality in sepsis patients: a multicenter analysis based on the eICU Collaborative Research Database.Frontiers in medicine · 2026Article
- Association between the direct bilirubin to lymphocyte ratio and mortality in patients with necrotizing fasciitis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Early increase in red cell distribution width-to-platelet ratio is associated with poor prognosis in sepsis patients: a retrospective cohort study.Frontiers in medicine · 2026Article
- Article
- Red cell distribution width and related indices in relation to target-organ damage in children with hypertension.BMC pediatrics · 2025Article
- Utilizing machine learning models for predicting outcomes in acute pancreatitis: development and validation in three retrospective cohorts.BMC medical informatics and decision making · 2025Article
- Prognostic Value of Erythrogram Indicators and C-Reactive Protein Levels in Predicting Outcomes of Patients with Coronavirus Disease 2019.International journal of molecular sciences · 2025Article
- Combined glycated hemoglobin index and red cell distribution width predict in-hospital mortality in critically ill sepsis patients based on MIMIC-IV analysis.Scientific reports · 2025Article
- Red cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced chronic liver disease.World journal of gastroenterology · 2025Article
- Association of the ROX index with mortality in sepsis patients: a retrospective study.Frontiers in medicine · 2025Article
- Prognostic value of blood inflammatory composite markers in the survival of pediatric patients with secondary hemophagocytic lymphohistiocytosis.Frontiers in pediatrics · 2025Article
- Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients.Future science OA · 2024Article
- Association between platelet-to-red cell distribution width ratio and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective cohort study.Frontiers in neurology · 2024Article
- Associations of systolic blood pressure and in-hospital mortality in critically ill patients with acute kidney injury.International urology and nephrology · 2023Article
- Peripheral Inflammatory Markers in Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder at Adolescent Age.International journal of molecular sciences · 2023Article
- Association between red cell distribution width-to-platelet ratio and short-term and long-term mortality risk in patients with acute ischemic stroke.BMC neurology · 2023Article
- Predictive value of admission red cell distribution width-to-platelet ratio for 30-day death in patients with spontaneous intracerebral hemorrhage: an analysis of the MIMIC database.Frontiers in neurology · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As a novel inflammatory index, the ratio of red cell distribution width (RDW) to platelet count (RPR) may have prognostic value in some critical illnesses. However, studies on the prognostic influence of RPR in patients with sepsis are few. This study is aimed at investigating the association between RPR levels and 28-day mortality in patients with sepsis. Methods: Data of patients with sepsis were obtained from the Medical Information Mart for Intensive Care III database. The best cut-off value was calculated by establishing the receiver operating characteristic curve (ROC), and the predictive ability of different indicators was compared through the area under the curve (AUC). The association between RPR levels and 28-day mortality was assessed using the Cox proportional hazards model. Restrictive cubic spline analysis was applied to the multivariable Cox model to investigate the nonlinear relationship between RPR and 28-day mortality. Results: A total of 3367 patients with sepsis were included in the study. A nonlinear relationship was observed between RPR and 28-day mortality, showing a trend of a first rapid increase and a gradual increase. For the prediction of mortality, the best cut-off value for RPR was 0.109, with an AUC of 0.728 (95% confidence interval [CI]: 0.709-0.747). The predictive capability of RPR was superior to those of RDW, platelet, SOFA score, and SAPS II score. After adjusting for various confounding factors, high RPR was significantly associated with increased mortality with adjusted hazard ratios of 1.210 (95% CI: 1.045-1.400) for categorical variables and 2.826 (95% CI: 2.025-3.944) for continuous variables. Conclusion: Elevated RPR level is significantly correlated with a high risk of 28-day mortality in patients with sepsis and can be a new predictor of patient prognosis.
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