Evidence map›Paper›PMID 36204592›Full record

ArticleInternational journal of pharmaceutics: X2022

Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma.

H Alnemeh-Al Ali, A Griveau, F Artzner, A Dupont, N Lautram, M A Jourdain, J Eyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Nanotherapy of Glioblastoma-Where Hope Grows.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

H Alnemeh-Al AliUniv Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.
A GriveauUniv Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.
F ArtznerUniv Rennes, CNRS, IPR (Institut de Physique de Rennes), UMR 6251, F-35000 Rennes, France.
A DupontUniv Rennes, CNRS, Inserm, BIOSIT-UMS 3480, US_S 018, Rennes, France.
N LautramUniv Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.
M A JourdainUniv Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.
J EyerUniv Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NFL-TBS.40-63 peptide is a recently discovered peptide derived from the light neurofilament chain (NFL). In this study, we demonstrated that the Biotinylated-NFL-peptide (BIOT-NFL) can spontaneously self-assemble into well-organized nanofibers (approximately 5 nm width and several micrometers in length) in several solutions, whereas the typical self-assembly was not systematically observed from other peptides with or without coupling. The critical aggregation concentration that allows the BIOT-NFL-peptide to aggregate and auto associate was determined at 10

Indexed as

aCSF, artificial cerebrospinal fluidBIOT-NFL-peptide-nanofibersBIOT-NFL, the NFL-TBS.40–63 peptide coupled to the biotinCAC, critical aggregation concentrationDMEM, dulbecco's modified eagle mediumFAM-NFL, the NFL-TBS.40–63 peptide coupled to 5-carboxy-fluoresceinGlioblastomaGold nanoparticlesNFL-peptide, neurofilament light subunit derived 24 amino acid tubulin-binding site peptide NFL-TBS.40–63NFL-SCR, the scrambled NFL-TBS.40–63 peptide (with the same amino acids as the NFL-peptide but in a different order)NFL-TBS.40-63 peptidenude-NFL, the NFL-TBS.40–63 peptide with no labelingSDS, sodium dodecyl sulfateSelf-assemblyTargeted drug deliveryTEM, transmission electron microscopyUPLC, ultra-performance liquid chromatography systemXRS, x-ray scattering

Identifiers

PMID36204592
PMCPMC9529584

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.