Evidence map›Paper›PMID 36204565›Full record

ArticleFrontiers in cardiovascular medicine2022

Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice.

Katarzyna Kazmierczak, Jingsheng Liang, Michelle Gomez-Guevara, Danuta Szczesna-Cordary

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Katarzyna KazmierczakDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, United States.
Jingsheng LiangDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, United States.
Michelle Gomez-GuevaraDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, United States.
Danuta Szczesna-CordaryDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, United States.
University of Miami · US

Funding

Redefining The Role Of Myosin Essential Light Chain In Cardiac MuscleR01HL143830 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SZCZESNA-CORDARY, DANUTA · 2020 to 2023
$1.5M
The myosin light chain regulators of heart functionR56HL146133 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SZCZESNA-CORDARY, DANUTA · 2019 to 2019
$488k
NHLBI NIH HHS R01 HL143830NHLBI NIH HHS R56 HL146133
6 · The paper itself

Abstract

In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC,

Indexed as

myosin RLCphosphomimetic S15D and T160D RLCsphosphorylationreconstituted cardiac muscle preparationssuper-relaxed state of myosintransgenic mice

Identifiers

PMID36204565
PMCPMC9530205
OpenAlexW4297906642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.