ArticleInfection and drug resistance2022
The Effect of Thiamine, Ascorbic Acid, and the Combination of Them on the Levels of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) in Sepsis Patients.
Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05663164 (Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) in Perioperative Stress Response
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Matrix Metalloproteinase-9 (MMP-9) as a Therapeutic Target: Insights into Molecular Pathways and Clinical Applications.Pharmaceutics · 2025Review
- Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics.Annals of intensive care · 2025Article
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression.International journal of molecular sciences · 2025Review
- Vitamin C for sepsis: from mechanisms to individualized therapy.Frontiers in medicine · 2025Review
- Bioresponsive and transformable coacervate actuated by intestinal peristalsis for targeted treatment of intestinal bleeding and inflammation.Bioactive materials · 2024Article
- Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications.Cell communication and signaling : CCS · 2024Review
- Paper-Based Biosensor for the Detection of Sepsis Using MMP-9 Biomarker in FIP Mice Model.Biosensors · 2023Article
- The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma.Molecules (Basel, Switzerland) · 2023Review
- The role of intestinal immune cells and matrix metalloproteinases in inflammatory bowel disease.Frontiers in immunology · 2022Article
- Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis is a global health problem. Therapeutic agents continue to develop for the management of sepsis. Ascorbic acid and thiamine are currently potential agents intensively studied for their benefits in sepsis. Methods: This study was a randomized controlled trial (RCT) with a pretest-posttest control group design. Randomization was using a computer. The research was conducted at Haji Adam Malik General Hospital Medan and Grand Medistra Hospital. Blood tests were at the Integrated Laboratory of the Faculty of Medicine, University of North Sumatra. The research was for 14 months. The number of patients in this study was 86 septic patients divided into four groups (NaCl, thiamine, ascorbic acid, and combination). The parameters measured were the enzyme MMP-9 and the enzyme TIMP-1. Results: The number of subjects who met the inclusion criteria was 147 patients. Fifty-three patients passed away during the monitoring period, and eight blood samples were damaged. The final data analyzed consisted of 86 subjects. Of the 86 septic patients obtained Based on initial MMP-9 values, MMP-9 levels increased in the 0.9% NaCl group (25.6%), while MMP-9 levels decreased after intervention in the thiamine, ascorbic acid, and combination groups but a significant decrease in MMP-9 was found in the ascorbic acid group (17.2%; p = 0.04) and the combination group (17.9%; p = 0.026). For TIMP-1 levels, a decreasing trend was only in the ascorbic acid (5.1%) and combination (5.9%) but not significant (p > 0.05). The highest MMP-9/TIMP-1 ratio was in septic patients receiving thiamine with a significant linear correlation (p < 0.05) between levels of MMP-9 and the MMP-9/TIMP-1 ratio with a moderate correlation level and significant negative correlation (p < 0.05) between TIMP-1 and the MMP-9/TIMP-1 with a moderate level of correlation. Conclusion: Administration of thiamine alone gives better advantages than ascorbic acid alone and their combination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.