Evidence map›Paper›PMID 36204266›Full record

ArticleiScience2022

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function.

Irene Mariam Roy, P V Anu, Samantha Zaunz, Srinu Reddi, Aravind M Giri, Rithika Saroj Sankar, Sarah Schouteden, Joerg Huelsken, Catherine M Verfaillie, Satish Khurana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Irene Mariam RoySchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
P V AnuSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Samantha ZaunzStem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Srinu ReddiSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Aravind M GiriSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Rithika Saroj SankarSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Sarah SchoutedenStem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Joerg HuelskenÉcole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Catherine M VerfaillieStem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Satish KhuranaSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Indian Institute of Science Education and Research Thiruvananthapuram · INKU Leuven · BEÉcole Polytechnique Fédérale de Lausanne · CH

Funding

Wellcome Trust
6 · The paper itself

Abstract

Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1α supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show that integrin signaling regulates

Indexed as

Biological sciencescell biologystem cells research

Identifiers

PMID36204266
PMCPMC9530850
OpenAlexW4296381348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.