Evidence map›Paper›PMID 36204214›Full record

ArticleMaterials today. Bio2022

Versatile nanorobot hand biosensor for specific capture and ultrasensitive quantification of viral nanoparticles.

Rui Li, Ya Zhao, Hongli Fan, Mingqian Chen, Wenjun Hu, Qiang Zhang, Meilin Jin, Gang L Liu, Liping Huang

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  3. Treatment of lung diseasesMaterials today. Bio · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rui LiCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Ya ZhaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China.
Hongli FanCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Mingqian ChenCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Wenjun HuCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Qiang ZhangCollege of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, PR China.
Meilin JinNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China.
Gang L LiuCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Liping HuangCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Huazhong University of Science and Technology · CNHuazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate determination of the concentration and viability of the viral vaccine vectors is urgently needed for preventing the spread of the viral infections, but also supporting the development and assessment of recombinant virus-vectored vaccines. Herein, we describe a nanoplasmonic biosensor with nanoscale robot hand structure (Nano RHB) for the rapid, direct, and specific capture and quantification of adenovirus particles. The nanorobot allows simple operation in practical applications, such as real-time monitoring of vaccine quantity and quality, and evaluation of vaccine viability. Modification of the Nano RHB with branched gold nanostructures allow rapid and efficient assessment of human adenovirus viability, with ultrahigh detection sensitivity of only 100 copies/mL through one-step sandwich method. Nano RHB detection results were consistent with those from the gold standard median tissue culture infectious dose and real-time polymerase chain reaction assays. Additionally, the Nano RHB platform showed high detection specificity for different types of viral vectors and pseudoviruses. Altogether, these results demonstrate that the Nano RHB platform is a promising tool for efficient and ultrasensitive assessment of vaccines and gene delivery vectors.

Indexed as

BiosensorLabel-free detectionNanoparticlesSurface plasmon resonanceVirus vector

Identifiers

PMID36204214
PMCPMC9531290
OpenAlexW4297328591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.