Evidence map›Paper›PMID 36204184›Full record

ArticleTransplantation direct2022

The Impact of Nutritional Supplementation on Donor Kidneys During Oxygenated Ex Vivo Subnormothermic Preservation.

Rabindra N Bhattacharjee, Ashley Jackson, Aushanth Ruthirakanthan, Smriti Juriasingani, Max A Levine, Larry Jiang, Ram Patel, Mahms Richard-Mohamed, Sheryl Forrest, Sevanthi Ravichandran and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rabindra N BhattacharjeeDepartment of Surgery, Schulich Medicine and Dentistry, Western University, London, ON, Canada.
Ashley JacksonSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Aushanth RuthirakanthanSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Smriti JuriasinganiSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Max A LevineMulti Organ Transplant Program, London Health Sciences Centre, London, ON, Canada.
Larry JiangSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ram PatelSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Mahms Richard-MohamedMulti Organ Transplant Program, London Health Sciences Centre, London, ON, Canada.
Sheryl ForrestMulti Organ Transplant Program, London Health Sciences Centre, London, ON, Canada.
Sevanthi RavichandranSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Alp SenerDepartment of Surgery, Schulich Medicine and Dentistry, Western University, London, ON, Canada.
Patrick P LukeDepartment of Surgery, Schulich Medicine and Dentistry, Western University, London, ON, Canada.
Western University · CALondon Health Sciences Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests that nutritional supplementation during normothermic ex vivo perfusion improves organ preservation. However, it is unclear whether the same benefit is observed during room temperature (subnormothermic) oxygenated perfusion. In this study, we tested the impact of providing complete nutrition during subnormothermic perfusion on kidney outcomes. Methods: Porcine kidneys were recovered after 30 min of cross clamping the renal artery in situ to simulate warm ischemic injury. After flushing with preservation solution, paired kidneys were cannulated and randomly assigned to perfusion with either (1) hemoglobin-carrier hemoglobin-based oxygen carrier or (2) hemoglobin-based oxygen carrier + total parenteral nutrition (TPN) for 12 h at 22 °C. To mimic reperfusion injury, all kidneys were reperfused with whole blood for an additional 4 h at 37 °C. Kidney function and damage were assessed. Results: Kidneys preserved with or without TPN performed equally well, showing similar renal function postreperfusion. Histological findings indicated similar levels of damage from apoptosis staining and acute tubular necrosis scores in both groups. Additionally, markers of renal damage (KIM-1) and inflammation (IL-6; high-mobility group box 1) were similar between the groups. Conclusions: Unlike other studies using normothermic oxygenated perfusion platforms, nutritional supplementation does not appear to provide any additional benefit during ex vivo kidney preservation over 12 h evaluated by whole blood-based reperfusion method at subnormothermic temperature. Further study should include a kidney autotransplant model to assess the role of TPN in vivo.

Identifiers

PMID36204184
PMCPMC9529041
OpenAlexW4297895612

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.