Evidence map›Paper›PMID 36204141›Full record

ArticleFrontiers in molecular neuroscience2022

A multifaceted evaluation of microgliosis and differential cellular dysregulation of mammalian target of rapamycin signaling in neuronopathic Gaucher disease.

Zhenting Zhang, Xiaohong Wang, Yi Lin, Dao Pan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zhenting ZhangDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Xiaohong WangDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Yi LinDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Dao PanDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

Gaucher disease:Treatment of neurodegenerative diseaseR01NS086134 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI PAN, DAO · 2013 to 2017
$2.1M
Manipulation of microRNA for CNS delivery: implication to treatment of neurological LSDR56NS114124 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI PAN, DAO · 2020 to 2020
$557k
NINDS NIH HHS R01 NS086134NINDS NIH HHS R56 NS114124
6 · The paper itself

Abstract

Neuronopathic Gaucher disease (nGD) is an inherited neurodegenerative disease caused by mutations in

Indexed as

disease-associated microgliaGaucher diseaseLamp1mTORneurodegenerative disordersneuroinflammationreactive astrocytesTmem119

Identifiers

PMID36204141
PMCPMC9530712
OpenAlexW4296482393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.