ArticleFrontiers in endocrinology2022
Chinese famine exposure in early life and metabolic obesity phenotype in middle age: Results from the China health and retirement longitudinal study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Secular trends in age at menarche among Han Chinese females in Shanghai: a large-scale community-based study.BMC women's health · 2025Article
- Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.Molecular metabolism · 2025Article
- Severe maternal undernutrition during pregnancy and its long-term effects on the offspring health, with a focus on kidney health.Pediatric nephrology (Berlin, Germany) · 2025Review
- In utero and childhood exposure to the great Chinese famine and risk of aging in adulthood.Scientific reports · 2024Article
- Associations of concurrent early-life famine exposure and adulthood obesity with type 2 diabetes mellitus in middle-aged Chinese.Journal of diabetes · 2024Article
- Evaluating the association of female obesity with the risk of live birth following IVF: Implications for clinical practice.The practising midwife · 2024Article
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Authors and funding
10 authors at 3 institutions in 1 country.
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Abstract
Objective: To assess the association between early life exposure to famine and the risk of metabolic obesity phenotypes among adults in middle age. Methods: The study selected two comparison groups. Comparison A consisted of a non-exposed group born between 1963-1965 from the China Health and Retirement Longitudinal Study (CHARLS) 2015 wave (N=862) and a fetal-exposed group born between 1959-1961 from the 2011 wave (N=507). Comparison B consisted of an early childhood-exposed group born between 1955-1957 from the 2011 wave (N=830) and a fetal-exposed group born between 1959-1961 from the 2015 wave (N=552). Multivariable logistic regressions were conducted to explore the associations between different periods of famine exposure and obesity, metabolic health status, and metabolic obesity phenotypes, with stratification by sex. Results: Compared with the non-exposed group, participants exposed to famine in the fetal period had a significantly lower risk of overweight/obesity ( Conclusion: Exposure to famine in early life increased the risk of metabolically unhealthy status in adulthood. Different metabolic subtypes should be identified at an early stage and followed by classification, intervention, and treatment.
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