Evidence map›Paper›PMID 36203998›Full record

ArticleFrontiers in neurology2022

Impact of type of oral anticoagulants in patients with cerebral microbleeds after atrial fibrillation-related ischemic stroke or TIA: Results of the NOACISP-LONGTERM registry.

Benjamin Wagner, Lisa Hert, Alexandros A Polymeris, Sabine Schaedelin, Johanna M Lieb, David J Seiffge, Christopher Traenka, Sebastian Thilemann, Joachim Fladt, Valerian L Altersberger and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03826927 (New Oral Anticoagulants in Stroke Patients-Long Term Prevention of Recurrent Stroke in Patients With Atrial Fibrillation- a National Prospective Registry), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03826927 completednot on this map

New Oral Anticoagulants in Stroke Patients-Long Term Prevention of Recurrent Stroke in Patients With Atrial Fibrillation- a National Prospective Registry (NOACISP Long Term)

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2013 to 2021Enrolled1,023ConditionsStroke, Atrial FibrillationArmstreatment with NOACs or VKAs
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Benjamin WagnerDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Lisa HertDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Alexandros A PolymerisDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Sabine SchaedelinClinical Trial Unit, University Hospital Basel and University of Basel, Basel, Switzerland.
Johanna M LiebDepartment of Diagnostic and Interventional Neuroradiology, Clinic for Radiology and Nuclear Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
David J SeiffgeDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Christopher TraenkaDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Sebastian ThilemannDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Joachim FladtDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Valerian L AltersbergerDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Annaelle ZietzDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Tolga D DittrichDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Urs FischDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Henrik GensickeDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Gian Marco De MarchisDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Leo H BonatiDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Philippe A LyrerDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Stefan T EngelterDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Nils PetersDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
University of Basel · CHUniversity Hospital of Basel · CHFelix Platter-Hospital · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cerebral microbleeds (CMBs) may have a differential impact on clinical outcome in stroke patients with atrial fibrillation (AF) treated with different types of oral anticoagulation (OAC). Methods: Observational single-center study on AF-stroke-patients treated with OAC. Magnetic-resonance-imaging was performed to assess CMBs. Outcome measures consisted of recurrent ischemic stroke (IS), intracranial hemorrhage (ICH), death, and their combined analysis. Functional disability was assessed by mRS. Using adjusted logistic regression and Cox proportional-hazards models, we assessed the association of the presence of CMBs and OAC type (vitamin K antagonists [VKAs] vs. direct oral anticoagulants [DOACs]) with clinical outcome. Results: Of 310 AF-stroke patients treated with OAC [DOACs: Conclusions: In AF-stroke patients treated with OAC, the presence of CMBs was associated with an unfavorable composite outcome for both VKAs and DOACs, with a higher risk for recurrent IS than for ICH. Strokes were numerically higher under VKAs and increased in the presence of CMBs. Clinical trial registration: http://www.clinicaltrials.gov, Unique identifier: NCT03826927.

Indexed as

anticoagulationatrial fibrillationcerebral microbleedsdirect-acting oral anticoagulantsmall vessel diseasestrokevitamin K anticoagulants

Identifiers

PMID36203998
PMCPMC9531011
OpenAlexW4296396571

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.