Evidence map›Paper›PMID 36203961›Full record

ArticleBioactive materials2023

Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment.

Zhi-Chao Hu, Jia-Qi Lu, Tai-Wei Zhang, Hai-Feng Liang, Hao Yuan, Di-Han Su, Wang Ding, Rui-Xian Lian, Yu-Xiang Ge, Bing Liang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Zhi-Chao HuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jia-Qi LuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Tai-Wei ZhangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hai-Feng LiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hao YuanKey Laboratory of Advanced Display and System Applications of Ministry of Education, Shanghai University, Shanghai, 200072, China.
Di-Han SuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wang DingDepartment of Orthopedics Surgery, Minhang Hospital, Fudan University, Shanghai, 201100, China.
Rui-Xian LianKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yu-Xiang GeDepartment of Orthopedics Surgery, Minhang Hospital, Fudan University, Shanghai, 201100, China.
Bing LiangDepartment of Orthopedic Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, China.
Jian DongDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xiao-Gang ZhouDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Li-Bo JiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Sun Yat-sen University · CNFudan University · CNEast China University of Science and Technology · CNShanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The electrical microenvironment plays an important role in bone repair. However, the underlying mechanism by which electrical stimulation (ES) promotes bone regeneration remains unclear, limiting the design of bone microenvironment-specific electroactive materials. Herein, by simple co-incubation in aqueous suspensions at physiological temperatures, biocompatible regenerated silk fibroin (RSF) is found to assemble into nanofibrils with a β-sheet structure on MXene nanosheets, which has been reported to inhibit the restacking and oxidation of MXene. An electroactive hydrogel based on RSF and bioencapsulated MXene is thus prepared to promote efficient bone regeneration. This MXene/RSF hydrogel also acts as a piezoresistive pressure transducer, which can potentially be utilized to monitor the electrophysiological microenvironment. RNA sequencing is performed to explore the underlying mechanisms, which can activate Ca

Indexed as

Bone regenerationElectrical microenvironmentElectrical stimulationMXeneRegenerated silk fibroin

Identifiers

PMID36203961
PMCPMC9513113
OpenAlexW4296849524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.