ArticleFrontiers in physiology2022
Changes in aortic diameter induced by weight loss: The HELENA trial- whole-body MR imaging in a dietary intervention trial.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Multimodal imaging of acquired aortic diseases: clinical efficacy, comparative analysis, and future perspectives.The international journal of cardiovascular imaging · 2026Review
- Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study.Journal of the American Heart Association · 2025Article
- CIDEC/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation.Life metabolism · 2025Article
- The two-stage exploratory association between hypertension and physical examinations: a community-based biobank study.Frontiers in cardiovascular medicine · 2025Article
- Identification of serum biomarkers and therapeutic targets for aortic diseases in obesity through multi-omics analysis.Journal of thoracic disease · 2024Article
- Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection.Medicina (Kaunas, Lithuania) · 2024Article
- Obesity and the obesity paradox in abdominal aortic aneurysm.Frontiers in endocrinology · 2024Review
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
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Abstract
Obesity-related metabolic disorders such as hypertension, hyperlipidemia and chronic inflammation have been associated with aortic dilatation and resulting in aortic aneurysms in many cases. Whether weight loss may reduce the risk of aortic dilatation is not clear. In this study, the diameter of the descending thoracic aorta, infrarenal abdominal aorta and aortic bifurcation of 144 overweight or obese non-smoking adults were measured by MR-imaging, at baseline, and 12 and 50 weeks after weight loss by calorie restriction. Changes in aortic diameter, anthropometric measures and body composition and metabolic markers were evaluated using linear mixed models. The association of the aortic diameters with the aforementioned clinical parameters was analyzed using Spearman`s correlation. Weight loss was associated with a reduction in the thoracic and abdominal aortic diameters 12 weeks after weight loss (predicted relative differences for Quartile 4: 2.5% ± 0.5 and -2.2% ± 0.8,
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