Evidence map›Paper›PMID 36203819›Full record

Trial reportDrug design, development and therapy2022

Remimazolam for the Prevention of Emergence Delirium in Children Following Tonsillectomy and Adenoidectomy Under Sevoflurane Anesthesia: A Randomized Controlled Study.

Xue Yang, Chuantao Lin, Sisi Chen, Yuezhou Huang, Qiong Cheng, Yusheng Yao

3 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 63 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 6 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07191652 completednot on this mapstarted 2026, after this paper: background citation

The Association Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and the Quality of Postoperative Recovery in Pediatric Otolaryngology Cases Monitored With Perioperative Bispectral Index

TypeobservationalSponsorIstanbul University - CerrahpasaRan2026 to 2026Enrolled128ConditionsEar Throat Nose Surgery, Delirium - Postoperative, Pain Postoperative
NCT07394647 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Emergence Agitation and Delirium After Pediatric Tonsillectomy and Adenoidectomy: A Randomized, Double-Blind, Interventional Study

TypeinterventionalSponsorThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityRan2026 to 2026Enrolled120ConditionsEmergence Agitation, Emergence DeliriumArmsActive taVNS Group, Sham stimulation group
NCT07408037 narecruitingnot on this mapstarted 2024, after this paper: background citation

Preoperative Anxiety and Postoperative Recovery Delirium Observation in Children Who Underwent Gamified Breathing Exercise

TypeinterventionalSponsorBozok UniversityRan2024 to 2026Enrolled80ConditionsPreoperative Anxiety (Ameliyat Öncesi Anksiyete), Emergence Delirium (Derlenme Deliryumu), Postoperative Complications, Pediatric PatientsArmsGamified Breathing Exercises
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  10. Application of oral midazolam for preoperative sedation in pediatric tonsillectomy and adenoidectomy and its effects on emergence delirium.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  14. Determination of the EDDrug design, development and therapy · 2026
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  17. [Application of Remimazolam in Pediatric Adenoidectomy and Tonsillectomy Anesthesia and Its Effect on Emergence Agitation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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  18. Effect of Airway Devices on Emergence Delirium in Pediatric Strabismus Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xue Yang *Department of Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People's Republic of China.
Chuantao Lin *Department of Anesthesiology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
Sisi ChenDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People's Republic of China.ORCID 0000-0002-1551-7876
Yuezhou HuangDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People's Republic of China.ORCID 0000-0003-3778-1958
Qiong ChengDepartment of Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People's Republic of China.
Yusheng YaoDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People's Republic of China.ORCID 0000-0001-8488-8876
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To identify the effectiveness of remimazolam at the end of tonsillectomy and adenoidectomy for preventing emergence delirium in children under sevoflurane anesthesia. Patients and Methods: One hundred and four patients aged 3-7 years scheduled for tonsillectomy and adenoidectomy under sevoflurane anesthesia were recruited. Patients were randomly assigned to receive either remimazolam 0.2 mg kg Results: Emergence delirium occurred in 6 of 51 (12%) patients receiving remimazolam versus 22 of 50 (44%) patients receiving saline (risk difference 32% [95% confidence interval, 16% to 49%], relative risk 0.27 [95% confidence interval, 0.12 to 0.60]; Conclusion: In children undergoing tonsillectomy and adenoidectomy, administration of remimazolam 0.2 mg kg

Indexed as

AnesthesiaEmergence DeliriumMethyl EthersTonsillectomyAdenoidectomyAnesthesia Recovery PeriodBenzodiazepinesChildDouble-Blind MethodHumansPostoperative PainSaline SolutionSevofluraneBenzodiazepinesMethyl EthersremimazolamSaline SolutionSevofluraneemergence deliriumgeneral anesthesiapediatric anesthesiaremimazolam

Identifiers

PMID36203819
PMCPMC9531607
OpenAlexW4297984294

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.