Evidence map›Paper›PMID 36203645›Full record

ArticlePain reports

Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach.

Matthew C Mauck, Aileen F Aylward, Chloe E Barton, Brandon Birckhead, Timothy Carey, Diane M Dalton, Aaron J Fields, Julie Fritz, Afton L Hassett, Anna Hoffmeyer and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07296653 (Efficacy of Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07296653 early_phase1recruitingnot on this map

Efficacy of Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP) - A Randomized Control Trial

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2025 to 2027Enrolled60ConditionsChronic Non-specific Low Back PainArmsDextrose 15% and lidocaine 1% infiltration, Lidocaine 1% infiltration
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. A meta-model of low back pain to examine collective expert knowledge of treatment effects and their mechanisms.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Matthew C MauckDepartments ofAnesthesiology.
Aileen F AylwardEmergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chloe E BartonDepartments ofAnesthesiology.
Brandon BirckheadDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Timothy CareyDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill NC, USA.
Diane M DaltonDepartment of Physical Therapy, Boston University, College of Health and Rehabilitation Sciences, Sargent, Boston MA, USA.
Aaron J FieldsDepartment of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
Julie FritzDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.
Afton L HassettDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Anna HoffmeyerUniversity of North Carolina at Chapel Hill, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA.
Sara B JonesDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Samuel A McLeanDepartments ofAnesthesiology.
Wolf E MehlingDepartment of Family and Community Medicine, University of California San Francisco, San Francisco, CA, USA.
Conor W O'NeillSection of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, USA.
Michael J SchneiderDepartment of Physical Therapy and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
David A WilliamsDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Patricia ZhengSection of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, USA.
Ajay D WasanDepartments of Anesthesiology and Perioperative Medicine and Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

University of Michigan BACPAC Mechanistic Research CenterU19AR076734 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, HASSETT, AFTON L · 2019 to 2023
$12.2M
SMART Stepped Care Management for Low Back Pain in Military Health SystemUH3AT009763 · NCCIH · UNIVERSITY OF UTAH · PI FRITZ, JULIE M, RHON, DAN · 2019 to 2022
$6.2M
NCCIH NIH HHS UH3 AT009763NIAMS NIH HHS U19 AR076734
6 · The paper itself

Abstract

Introduction: Chronic low back pain (cLBP) is highly prevalent in the United States and globally, resulting in functional impairment and lowered quality of life. While many treatments are available for cLBP, clinicians have little information about which specific treatment(s) will work best for individual patients or subgroups of patients. The Back Pain Research Consortium, part of the National Institutes of Health Helping to End Addiction Long-term Objective: The primary objective of this article is to provide an update on evidence-based cLBP interventions and describe the process of reviewing and selecting interventions for inclusion in the clinical trial. Methods: A working group of cLBP experts reviewed and selected interventions for inclusion in the clinical trial. The primary evaluation measures were strength of evidence and magnitude of treatment effect. When available in the literature, duration of effect, onset time, carryover effect, multimodal efficacy, responder subgroups, and evidence for the mechanism of treatment effect or biomarkers were considered. Conclusion: The working group selected 4 leading, evidence-based treatments for cLBP to be tested in the clinical trial and for use in routine clinical treatment. These treatments include (1) duloxetine, (2) acceptance and commitment therapy, (3) a classification-based exercise and manual therapy intervention, and (4) a self-management approach. These interventions each had a moderate to high level of evidence to support a therapeutic effect and were from different therapeutic classes.

Indexed as

Chronic low back painInterventionsPragmatic clinical trial

Identifiers

PMID36203645
PMCPMC9529058

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.