Evidence map›Paper›PMID 36203273›Full record

ArticleObesity (Silver Spring, Md.)2023

Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females.

Faiza Kalam, Rand T Akasheh, Sofia Cienfuegos, Aparna Ankireddy, Kelsey Gabel, Mark Ezpeleta, Shuhao Lin, Chandra M Tamatam, Sekhar P Reddy, Bonnie Spring and 2 more

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Faiza KalamDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.
Rand T AkashehDepartment of Nutrition and Dietetics, American University of Madaba, Madaba, Jordan.
Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Aparna AnkireddyDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Mark EzpeletaDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Shuhao LinDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Chandra M TamatamDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, USA.
Sekhar P ReddyDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, USA.
Bonnie SpringDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0003-0692-9868
Seema A KhanDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9279-9934

Funding

Mediating Role of Gut Microbiota in the Regulation of Colorectal Cancer Risk in the Context of Time-restricted Eating and Calorie RestrictionR01CA257807 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Lisa Tussing-Humphreys, Krista Amy Varady · 2021 to 2026
$5.4M
Cancer Prevention, Control, and Survivorship Research Training ProgramT32CA193193 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Brian L Hitsman, BETINA YANEZ · 2015 to 2026
$3.8M
Alternate day fasting combined with exercise for the treatment of NAFLDR01DK119783 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VARADY, KRISTA AMY · 2019 to 2022
$1.4M
NCI NIH HHS R01 CA257807NCI NIH HHS T32 CA193193NIDDK NIH HHS R01 DK119783
6 · The paper itself

Abstract

objectiveConcerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females.

methodsThis is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11).

resultsAfter 8 weeks, body weight decreased in premenopausal females (-3% ± 2%) and postmenopausal females (-4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (-14% ± 32%) and postmenopausal females (-13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged.

conclusionsIn premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.

Indexed as

Intermittent FastingPostmenopauseProgesteroneAdultAndrogensDehydroepiandrosteroneEstradiolFemaleGonadal Steroid HormonesHumansSex Hormone-Binding GlobulinTestosteroneAndrogensDehydroepiandrosteroneEstradiolGonadal Steroid HormonesProgesteroneSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID36203273
PMCPMC9877115

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.