ArticlePerioperative medicine (London, England)2022
Early postoperative serum aspartate aminotransferase for prediction of post-hepatectomy liver failure.
Article in Perioperative medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Elevated Liver Enzymes Can Predict Complications Early After Pancreatic Resection.Journal of clinical medicine · 2026Article
- Tolerance to ischemia-reperfusion injury in laparoscopic vs. open living donor hepatectomy with intermittent hepatic inflow occlusion: a retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Enhancing future liver remnant hypertrophy: innovative preoperative strategies and emerging technologies.Translational gastroenterology and hepatology · 2026Review
- Machine learning-based prediction of postoperative mortality risk after abdominal surgery.World journal of gastrointestinal surgery · 2025Article
- Early postoperative liver function parameters as predictors of post-hepatectomy liver failure.Frontiers in surgery · 2025Article
- Extracellular NADCommunications biology · 2024Article
- Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure.Discover oncology · 2024Article
- [Transaminases on the First Day After Hepatectomy and Prediction of Out-comes in Malignant Disease].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-hepatectomy liver failure (PHLF) is a serious complication of hepatectomy. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data on or after postoperative day (POD) 5, which may delay treatment for patients at risk. The present study aimed to determine the associations between early postoperative (POD1) serum aminotransferase levels and PHLF.
methodsThe medical records of patients who underwent hepatectomy at Ramathibodi Hospital from January 2008 to December 2019 were retrospectively examined. Patients were classified into PHLF and non-PHLF groups. Preoperative characteristics, intraoperative findings, and early postoperative laboratory data (serum AST, ALT, bilirubin, and international normalized ratio (INR) on POD0 to POD5) were analyzed.
resultsA total of 890 patients were included, of whom 31 (3.4%) had PHLF. Cut-off points for AST of 260 U/L and ALT of 270 U/L on POD1 were predictive of PHLF. In multivariate analysis, AST > 260 U/L on POD1, ICG-R15, major hepatectomy, blood loss, and INR were independently associated with PHLF.
conclusionsEarly warning from elevated serum AST on POD1, before a definitive diagnosis of PHLF is made on POD5, can help alert physicians that a patient is at risk, meaning that active management and vigilant monitoring can be initiated as soon as possible.
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Registered trials
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