Evidence map›Paper›PMID 36203127›Full record

ArticleBMC medical imaging2022

Brain magnetic resonance imaging findings among children with epilepsy in two urban hospital settings, Kampala-Uganda: a descriptive study.

Denise Apolot, Geoffrey Erem, Rita Nassanga, Daniel Kiggundu, Crescent Max Tumusiime, Anneth Teu, Alex Mwesigwa Mugisha, Robert Sebunya

Open access · goldAbstract read
In one paragraph

Article in BMC medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Denise ApolotDepartment of Radiology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. deniseapolot@rocketmail.com.
Geoffrey EremDepartment of Radiology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Rita NassangaDepartment of Radiology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Daniel KiggunduClinical Epidemiology Unit, College of Health Sciences, Makerere University, Kampala, Uganda.
Crescent Max TumusiimeDepartment of Radiology, Mother Kevin Postgraduate Medical School, Uganda Martyrs University School of Medicine, Kampala, Uganda.
Anneth TeuDepartment of Radiology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Alex Mwesigwa MugishaDepartment of Radiology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Robert SebunyaDepartment of Pediatrics, Mother Kevin Postgraduate Medical School, Uganda Martyrs University School of Medicine, Kampala, Uganda.
Makerere University · UGUganda Martyrs University · UG

Funding

Health Professions Education and training for strengthening the health system and services in UgandaR25TW011213 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KIGULI, SARAH · 2018 to 2022
$3.4M
FIC NIH HHS R25 TW011213
6 · The paper itself

Abstract

backgroundEpilepsy is one of the most common neurological conditions in children worldwide. Its presentation is heterogeneous, with diverse underlying aetiology, clinical presentation, and prognosis. Structural brain abnormalities are among the recognized causes of epilepsy. Brain Magnetic Resonance Imaging (MRI) is the imaging modality of choice for epilepsy workup. We aimed to determine the prevalence and describe the structural abnormalities identified in the brain MRI studies performed on children with epilepsy from two urban hospitals in Kampala, Uganda.

methodsThis was a cross-sectional descriptive study performed at two urban hospital MRI centres. The study population was 147 children aged 1 day to 17 years with confirmed epilepsy. Brain MRI was performed for each child and a questionnaire was used to collect clinical data.

resultsThe prevalence of structural abnormalities among children with epilepsy was 74.15% (109 out of 147). Of these, 68.81% were male, and the rest were female. Among these, the majority, 40.14% (59 of 144) were aged 1 month to 4 years. Acquired structural brain abnormalities were the commonest at 69.22% with hippocampal sclerosis (HS) leading while disorders of cortical development were the most common congenital causes. An abnormal electroencephalogram (EEG) was significant for brain MRI abnormalities among children with epilepsy with 95% of participants with an abnormal EEG study having epileptogenic structural abnormalities detected in their brain MRI studies. CONCLUSION AND RECOMMENDATION: Two-thirds of children with epilepsy had structural brain abnormalities. Abnormal activity in the EEG study was found to positively correlate with abnormal brain MRI findings. As such, EEG study should be considered where possible before MRI studies as a determinant for children with epilepsy who will be having imaging studies done in the Ugandan setting.

Indexed as

EpilepsyBrainChildCross-Sectional StudiesElectroencephalographyFemaleHospitals, UrbanHumansMagnetic Resonance ImagingMaleUgandaAcquiredCongenitalEpilepsyMagnetic resonance imagingStructural abnormality

Identifiers

PMID36203127
PMCPMC9541090
OpenAlexW4303183983

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.