ArticleNature chemistry2022
An autonomous portable platform for universal chemical synthesis.
Article in Nature chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- From scrap to prime: Designing high-performance alloys from dirty feedstocks with machine learning.Science advances · 2026Article
- AI for Accelerated Materials Discovery: From Generative Design to Autonomous Realization.Chemical reviews · 2026Article
- Validated workflows for preparing and characterizing core-stained and surface-labeled fluorescent polymer particles with simple commercial automation tools.Analytical and bioanalytical chemistry · 2026Article
- AutoLabs: cognitive multi-agent systems with self-correction for autonomous chemical experimentation.Scientific reports · 2026Article
- RobInHood: a robotic chemist in a fume hood.Digital discovery · 2026Article
- Chemputer and chemputation-A universal chemical compound synthesis machine.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Artificial Intelligence Empowered New Materials: Discovery, Synthesis, Prediction to Validation.Nano-micro letters · 2026Review
- Data-Driven Discovery of Polar Organic Cocrystals: Integration of Machine Learning and Automated Screening.Journal of the American Chemical Society · 2025Article
- Self-driving lab discovers principles for steering spontaneous emission beyond conventional Fourier optics.Nature communications · 2025Article
- Enabling technology for accelerated discovery of supramolecular materials.Chemical science · 2025Review
- Deep active optimization for complex systems.Nature computational science · 2025Article
- Article
- Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning.Beilstein journal of organic chemistry · 2025Review
- Printed polymer platform empowering machine-assisted chemical synthesis in stacked droplets.Nature communications · 2024Article
- Automation and machine learning augmented by large language models in a catalysis study.Chemical science · 2024Review
- Deductive machine learning models for product identification.Chemical science · 2024Article
- An Automated Robotic Interface for Assays: Facilitating Machine Learning in Drug Discovery by the Automation of Physicochemical Property Assays.ACS omega · 2024Article
- The relevance of sustainable laboratory practices.RSC sustainability · 2024Review
- Reinvent 4: Modern AI-driven generative molecule design.Journal of cheminformatics · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Robotic systems for synthetic chemistry are becoming more common, but they are expensive, fixed to a narrow set of reactions, and must be used within a complex laboratory environment. A portable system that could synthesize known molecules anywhere, on demand, and in a fully automated way, could revolutionize access to important molecules. Here we present a portable suitcase-sized chemical synthesis platform containing all the modules required for synthesis and purification. The system uses a chemical programming language coupled to a digital reactor generator to produce reactors and executable protocols based on text-based literature syntheses. Simultaneously, the platform generates a reaction pressure fingerprint, used to monitor processes within the reactors and remotely perform a protocol quality control. We demonstrate the system by synthesizing five small organic molecules, four oligopeptides and four oligonucleotides, in good yields and purities, with a total of 24,936 base steps executed over 329 h of platform runtime.
Indexed as
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36202987What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.