ArticleScientific reports2022
Association between albumin or prealbumin levels at different stages and prognosis in severe acute pancreatitis: a 5-year retrospective study.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Association between lactate-to-albumin ratio and 30-day all-cause mortality in patients with acute pancreatitis-associated acute kidney injury.Scientific reports · 2026Article
- Review
- Spexin as a Novel Biomarker for Predicting Disease Severity and Mortality in Acute Pancreatitis.International journal of molecular sciences · 2026Article
- Glucose-to-albumin ratio predicts short-term mortality in critically ill patients with acute pancreatitis.Scientific reports · 2026Article
- Association between the Fibrosis-4 index and mortality risk in acute pancreatitis.Frontiers in medicine · 2026Article
- Blood urea nitrogen to albumin ratio as a robust predictor of in-hospital mortality in patients with predicted severe acute pancreatitis: a retrospective multicenter observational study.International journal of surgery (London, England) · 2026Observational
- Fluid therapy strategies in acute pancreatitis: Randomized controlled trial comparing dextran and Ringer's lactate.World journal of gastrointestinal surgery · 2025Article
- Development of a novel nomogram to predict the prognosis of acute pancreatitis in pregnancy.BMC gastroenterology · 2025Article
- Association of blood urea nitrogen to albumin ratio with mortality in acute pancreatitis.Scientific reports · 2025Article
- Advances in the Management of Fluid Resuscitation in Acute Pancreatitis: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- The difference in hematocrit and albumin levels and the risk of sepsis for patients with acute pancreatitis: a retrospective cohort study based on the MIMIC-IV database.Sao Paulo medical journal = Revista paulista de medicina · 2025Article
- Association between albumin infusion and sepsis risk of patients with acute pancreatitis.PloS one · 2025Article
- Prealbumin Adjusted Prognostic Nutritional Index May Predict the Postoperative Survival and Free Walking Abilities of Patients with Hip Fractures: A Multi-Center Follow-Up Study.Clinical interventions in aging · 2025Article
- Exploring the value of blood urea nitrogen-to-albumin ratio in patients with acute pancreatitis admitted to the intensive care unit: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Vancomycin is a risk factor for acute pancreatitis and increases the mortality rate in patients with severe pancreatitis.Frontiers in immunology · 2025Article
- Association between hematocrit-to-albumin ratio and acute kidney injury in patients with acute pancreatitis: a retrospective cohort study.Scientific reports · 2024Article
- Association between serum creatinine to albumin ratio and short- and long-term all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database.Frontiers in immunology · 2024Article
- Development and validation of a nomogram combining pain score with laboratory indicators for predicting persistent organ failure in acute pancreatitis: a retrospective cohort study.Frontiers in medicine · 2024Article
- Efficacy of integrated traditional Chinese and western medicine in managing mild-moderate acute pancreatitis: a real-world clinical perspective analysis.Frontiers in medicine · 2024Article
- Development and Validation of a Dynamic Nomogram for Predicting in-Hospital Mortality in Patients with Acute Pancreatitis: A Retrospective Cohort Study in the Intensive Care Unit.International journal of general medicine · 2023Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute pancreatitis (SAP) is a common abdominal disorder contributing to high mortality and open laparotomy rates. The role of exogenous infused albumin in fluid resuscitation or continuous therapy has always been an unanswered question. In early stage after onset, SAP patients with higher serum albumin or prealbumin show a better prognosis. In this study, we tried to disclose the linkage between albumin/prealbumin and SAP prognosis and establish a new goal-directed therapy involving albumin and prealbumin. Pearson's chi-squared test and the Mann-Whitney U test were used to compare the descriptive data between surviving and non-surviving patients. Three days, 4-7 days, 8-14 days and 15-28 days after SAP onset were defined as stages 1-4. The average concentrations of albumin and prealbumin were calculated, and receiver operating characteristic (ROC) curves were drawn to screen out the best cutoff values associated with poor prognostic outcomes, including laparotomy and failure to survive. Kaplan-Meier survival curves and log-rank tests were used to validate the effect of the cut-off values. A total of 199 admitted patients were enrolled in this study. According to the analysis of the ROC curve, the serum albumin value should be raised to 35, 37, 40 and 42 g/L in the 1-4 stage after onset. Serum prealbumin values should be raised to 108, 180, and 181 g/L in stages 2-4 after onset. The validity of the above data was confirmed by Kaplan-Meier survival curves. Serum albumin and prealbumin levels in the early stage of SAP are significantly relevant to prognosis. Albumin should be infused from the fluid resuscitation stage to continuous therapy in order to reach the targets mentioned above. The increase in prealbumin depends on the early initiation of enteral nutrition and this also helps to ameliorate the prognosis.
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