ArticleScientific reports2022
A miniature fluorescence microscope for multi-plane imaging.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Protocol to improve gradient-index lens implantation in the mouse medial prefrontal cortex using NeuralGlider-assisted insertion.STAR protocols · 2026Article
- Dissecting neuronal circuit function and dysfunction in Alzheimer's disease mouse models: from conventional calcium imaging analysis to machine learning-based approaches.Frontiers in aging neuroscience · 2026Review
- Integrating optical neuroscience tools into touchscreen operant systems.Nature protocols · 2025Review
- Nonmechanical spectral domain optical coherence tomography using an electrowetting beam-scanner.Optics express · 2025Article
- Chip-Sized Lensless Holographic Microscope for Real-Time On-Chip Biological Sensing.Sensors (Basel, Switzerland) · 2025Article
- Population imaging of internal state circuits relevant to psychiatric disease: a review.Neurophotonics · 2025Review
- Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods.Current protocols · 2025Article
- Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning.Addiction neuroscience · 2024Article
- Tunable liquid lens for three-photon excitation microscopy.Biomedical optics express · 2024Article
- Imaging distinct neuronal populations with a dual channel miniscope.Frontiers in neuroscience · 2024Article
- Pupil engineering for extended depth-of-field imaging in a fluorescence miniscope.Neurophotonics · 2023Article
- Fabrication and characterization of a two-dimensional individually addressable electrowetting microlens array.Optics express · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Miniature fluorescence microscopes are becoming an increasingly established tool to investigate neural circuits in freely moving animals. In this work we present a lightweight one-photon microscope capable of imaging at different focal depths. The focal plane can be changed dynamically by modulating the pulse width of the control signal to a variable focus liquid lens, which is synchronized to the image sensor to enable changing focal plane between frames. The system was tested by imaging GCaMP7f expressing neurons in the mouse medial prefrontal cortex (mPFC) in vivo during open field test. Results showed that with the proposed design it is possible to image neurons across an axial scan of ~ 60 μm, resulting in a ~ 40% increase of total neurons imaged compared to single plane imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.