ArticleJournal of affective disorders2023
Long-term depressive symptoms and midlife brain age.
Article in Journal of affective disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Predictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial.Dialogues in clinical neuroscience · 2024Trial
- Accelerated Brain Aging in Young Women with Posttraumatic Stress Disorder.Experimental neurobiology · 2026Article
- The mediating role of obesity in the relationship between sleep duration and depressive symptoms: A population-based cross-sectional study.Metabolism open · 2026Article
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- Longitudinal brain-age predictions comprising long-duration spaceflight missions.NPJ microgravity · 2026Article
- Eukaryotic initiation factor 4E: a key factor of traumatic stress-induced depression-related cognitive decline at different age.Translational psychiatry · 2026Article
- Potential vulnerability and resilience to accelerated brain aging in women exposed to stressful life events: insights from the brain age prediction model.Neurobiology of stress · 2025Article
- Predictive model of neurocognitive functioning after acute coronary syndrome. A machine learning approach.Journal of cardiovascular and thoracic research · 2025Article
- Trajectories in depressive symptoms and midlife brain health.Translational psychiatry · 2024Article
- Early depressive manifestations in patients with dementia caused by Alzheimer's disease.Experimental and therapeutic medicine · 2024Article
- Facts and myths about use of esketamine for treatment-resistant depression: a narrative clinical review.Frontiers in psychiatry · 2024Review
- Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice.Frontiers in nutrition · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundEvidence suggests that depression may be a risk factor for dementia in older adults, but the link between depressive symptoms and brain health earlier in life is less understood. Our aim was to investigate the association between long-term depressive symptoms in young to mid-adulthood and a measure of brain age derived from structural MRI.
methodsFrom the Coronary Artery Risk Development in Young Adults study, we identified 649 participants (age 23-36 at baseline) with brain MRI and cognitive testing. Long-term depressive symptoms were measured with the Center for Epidemiological Studies Depression scale (CESD) six times across 25 years and analyzed as time-weighted averages (TWA). Brain age was derived using previously validated high dimensional neuroimaging pattern analysis, quantifying individual differences in age-related atrophy. Elevated depressive symptoms were defined as CES-D ≥16. Linear regression was used to test the association between TWA depressive symptoms, brain aging, and cognition.
resultsEach standard deviation (5-points) increment in TWA depression symptoms over 25 years was associated with one-year greater brain age (β: 1.14, 95 % confidence interval [CI]: 0.57 to 1.71). Participants with elevated TWA depressive symptoms had on average a 3-year greater brain age (β: 2.75, 95 % CI: 0.43 to 5.08). Moreover, elevated depressive symptoms were associated with higher odds of poor cognitive function in midlife (OR: 3.30, 95 % CI: 1.37 to 7.97). LIMITATIONS: Brain age was assessed at one time, limiting our ability to evaluate the temporality of depressive symptoms and brain aging.
conclusionsElevated depressive symptoms in early adulthood may have implications for brain health as early as in midlife.
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