ArticleJournal of psychopathology and clinical science2023
A gene-environment cascade theoretical framework of developmental psychopathology.
Article in Journal of psychopathology and clinical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Genetic nurture in intergenerational transmission of substance use.Nature communications · 2026Article
- Ethnic Discrimination Moderates Genetic Influences on Adolescent Internalizing and Externalizing Psychopathology.Behavior genetics · 2026Article
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.Development and psychopathology · 2025Article
- Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits.Molecular psychiatry · 2025Article
- Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention.Development and psychopathology · 2025Article
- Diagnostic Inclusion of Attachment Trauma: A Commentary on Farina and Schimmenti (2025).Clinical neuropsychiatry · 2025Article
- Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth.Journal of studies on alcohol and drugs · 2025Article
- Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors.Frontiers in psychiatry · 2025Article
- Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm.Behavior genetics · 2024Article
- Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample.Frontiers in psychiatry · 2024Article
- Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips Across Early Adolescence in the ABCD Study.Research on child and adolescent psychopathology · 2023Article
- Theories of psychopathology: Introduction to a special section.Journal of psychopathology and clinical science · 2023Article
- Examining protective factors for substance use problems and self-harm behavior during adolescence: A longitudinal co-twin control study.Development and psychopathology · 2022Article
- Early risk for child externalising symptoms: Examining genetic, prenatal, temperamental and parental influences.Infant and child developmentArticle
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Authors and funding
3 authors.
Funding
Abstract
Previous theories have emphasized genetic effects "inside the skin" via endophenotypes within the broader developmental psychopathology theory. Expanding on the mechanisms of gene-environment correlation, we propose a new integrative framework emphasizing how genetic effects "outside the skin" (Reiss & Leve, 2007) accumulate due to individual variation in social information processing in negative environments and sociocultural contexts as part of developmental cascades to psychopathology. In this gene-environment cascade theoretical framework, genetic predisposition for psychopathology, as well as stable traits and behaviors, can lead to negative environments via gene-environment correlations that can be exacerbated or buffered by an individual's social information processing. Moreover, these "environments" range from dyadic social relationships to broader sociocultural contexts. Over time, these processes exacerbate one another as part of developmental cascades, resulting in accumulating risk for psychopathology. By focusing on gene-environment correlations and integrating disparate social-emotional, cognitive, and sociocultural research domains, this framework delineates key processes by which early genetic predisposition can contribute to developmentally distinct and accumulating risk for psychopathology over the life course. Implications for intervention and methodological advances that facilitate testing models are presented. This new framework moves the field further away from genetic determinism by informing targets of early psychosocial prevention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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