Evidence map›Paper›PMID 36201640›Full record

ArticleThe Journal of infectious diseases2022

Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden.

Xiaohong Su, Wenjing Le, Xiaofeng Zhu, Sai Li, Baoxi Wang, Guillermo Madico, Zhaoyan Yang, Christine E Chaisson, Robert E McLaughlin, Sumanth Gandra and 7 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. PreclinicalFrontiers in immunology · 2025
    Article
  5. Article
  6. Sexually transmitted infections in Spain: Current status.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Xiaohong SuSexually Transmitted Disease Clinic, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Wenjing LeSexually Transmitted Disease Clinic, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Xiaofeng ZhuSexually Transmitted Disease Clinic, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Sai LiSexually Transmitted Disease Clinic, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Baoxi WangSexually Transmitted Disease Clinic, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Guillermo MadicoEnvironmental Health and Safety, Boston University, Boston, MA, USA.
Zhaoyan YangBiostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA.
Christine E ChaissonBiostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA.
Robert E McLaughlinInstitute for Life Science Entrepreneurship, Union, NJ, USA.
Sumanth GandraDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Jungwon YoonDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Bo ZhengDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Lisa A LewisDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Sunita GulatiDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
George W ReedDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Sanjay RamDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Peter A RiceDivision of Infectious Diseases, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
University of Massachusetts Chan Medical School · USChinese Academy of Medical Sciences Dermatology Hospital · CNBoston University · USChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

The TLR4/MD-2 signaling pathway in gonoccocal diseaseU19AI084048 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, BAOXI · 2009 to 2013
$13.1M
A novel vaccine against multidrug-resistant gonorrheaR01AI141181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY, RICE, PETER A. · 2019 to 2023
$4.3M
NIAID NIH HHS R01 AI141181NIAID NIH HHS U19 AI084048
6 · The paper itself

Abstract

backgroundLikelihood of Neisseria gonorrhoeae infection in women exposed to male sex partners with increasing N. gonorrhoeae burdens and enhancement by Chlamydia trachomatis is not defined.

methodsWe identified men with urethritis and their regular female sex partners. Exposure to N. gonorrhoeae burdens in men was compared in N. gonorrhoeae-infected versus -uninfected partners. Association of N. gonorrhoeae infection in women with burdens in male partners was estimated using logistic regression. Association of C. trachomatis coinfection and N. gonorrhoeae burdens in women adjusted for burdens in male partners was estimated by linear regression.

resultsIn total, 1816 men were enrolled; 202 had ≥2 partners, 91 who confirmed monogamy and were enrolled; 77% were married. Seventy were partners of N. gonorrhoeae-infected men; 58 (83%) were N. gonorrhoeae infected, 26 (45%) C. trachomatis coinfected. Infected women had partners with 9.3-fold higher N. gonorrhoeae burdens than partners of uninfected women (P = .0041). Association of N. gonorrhoeae infection in women with upper quartiles of N. gonorrhoeae burdens in partners increased (odds ratios ≥ 2.97)compared to the first quartile (P = .032). N. gonorrhoeae burdens in C. trachomatis-coinfected women were 2.82-fold higher than in C. trachomatis-uninfected women (P = .036).

conclusionsN. gonorrhoeae infections increased in women whose partners were infected with higher N. gonorrhoeae burdens. C. trachomatis coinfection was associated with increased N. gonorrhoeae burdens in women.

Indexed as

Chlamydia InfectionsCoinfectionGonorrheaChlamydia trachomatisFemaleHumansMaleNeisseria gonorrhoeaeChlamydia trachomatis infection in womenNeisseria gonorrhoeae

Identifiers

PMID36201640
PMCPMC10205615
OpenAlexW4302763567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.