Evidence map›Paper›PMID 36201591›Full record

ArticleScience (New York, N.Y.)2022

Electrochemical potential enables dormant spores to integrate environmental signals.

Kaito Kikuchi, Leticia Galera-Laporta, Colleen Weatherwax, Jamie Y Lam, Eun Chae Moon, Emmanuel A Theodorakis, Jordi Garcia-Ojalvo, Gürol M Süel

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Evolutionary bioenergetics of sporulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Early activation of bioenergetic metabolism powers bacterial spore germination.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. A Game of Life with dormancy.Proceedings. Biological sciences · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kaito Kikuchi *Molecular Biology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3051-3689
Leticia Galera-Laporta *Molecular Biology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-2453-896X
Colleen WeatherwaxMolecular Biology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Jamie Y LamDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9262-0271
Eun Chae MoonMolecular Biology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3070-9155
Emmanuel A TheodorakisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9845-6919
Jordi Garcia-Ojalvo *Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0002-3716-7520
Gürol M Süel *Molecular Biology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-0819-7867

Funding

Charge matters: Pursuing the most common, and least understood molecular interactions in cellsR35GM139645 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUEL, GUROL MEHMET · 2021 to 2025
$2.8M
Chemical design of amyloid targeting fluorescent probesRF1AG062362 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THEODORAKIS, EMMANUEL A, YANG, JERRY · 2018 to 2020
$2.1M
Electrical signaling in bacterial biofilmsR01GM121888 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUEL, GUROL MEHMET · 2017 to 2020
$2.0M
NIA NIH HHS RF1 AG062362NIGMS NIH HHS R01 GM121888NIGMS NIH HHS R35 GM139645
6 · The paper itself

Abstract

The dormant state of bacterial spores is generally thought to be devoid of biological activity. We show that despite continued dormancy, spores can integrate environmental signals over time through a preexisting electrochemical potential. Specifically, we studied thousands of individual

Indexed as

Bacillus subtilisPotassium-Hydrogen AntiportersSpores, BacterialElectrophysiological PhenomenaModels, BiologicalPotassiumPotassiumPotassium-Hydrogen Antiporters

Identifiers

PMID36201591
PMCPMC10593254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.