ArticleScience (New York, N.Y.)2022
A noncoding single-nucleotide polymorphism at 8q24 drives
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In one paragraph
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.Neuro-oncology · 2023Pooled it
- Synchronous diagnosis of multicentric glioma with distinct isocitrate dehydrogenase molecular profiles: a case report.CNS oncology · 2026Article
- Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.Cell · 2026Article
- Common genetic variation of the IGF2 gene and epithelial ovarian cancer risk in Chinese population.Discover oncology · 2026Article
- The New Tumor Predisposition Syndromes with Neuro-Oncological Relevance-A Comprehensive Review for Neuroradiologists.Clinical neuroradiology · 2026Review
- CSF1R and macrophage infiltration: Integrated magnetic resonance imaging radiomics and deep learning-driven models for the preoperative assessment of glioma.Chinese medical journal · 2026Article
- DNA copy number patterns reveal prognostic markers and elucidate mechanisms of evolution in IDH-mutant astrocytoma.Neuro-oncology · 2026Article
- Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Major Ethnic Populations Are Significantly Differentiated at the Glioblastoma Multiforme Candidate Loci.International journal of molecular sciences · 2026Article
- l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.The Journal of clinical investigation · 2026Article
- A rapid and ultrasensitive CRISPR-Cas12a assay for clinical detection of pathogens and mutations.Analytical and bioanalytical chemistry · 2026Article
- MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1.International journal of biological sciences · 2026Article
- Machine learning-integrated network toxicology uncovers glioma targets of DEHP.Frontiers in toxicology · 2026Article
- Circulating chromatin reveals the effects of disease-associated variants on gene regulation.bioRxiv : the preprint server for biology · 2025Article
- A MGMT Enhancer Variant is Associated with Glioma Susceptibility and Progression.Cellular and molecular neurobiology · 2025Article
- Support vector machine-based preoperative identification of IDH-Mutant low-grade gliomas in adult gliomas using clinical features.BMC neurology · 2025Article
- Systematic decoding of functional enhancer connectomes and risk variants in human glioma.Nature cell biology · 2025Article
- Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma.Neuro-oncology · 2025Article
- Genomewide association study of a homogeneous multiple sclerosis cohort: Tumefactive demyelination.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Illuminating the Noncoding Genome in Cancer Using Artificial Intelligence.Cancer research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 12 institutions in 4 countries.
Connor Yanchus *Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-9450-7982
Kristen L Drucker *Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6244-5863
Thomas M KollmeyerDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-0694-3224
Ricky TsaiCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-5916-6978
Warren Winick-NgMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany.ORCID 0000-0002-8716-5558
Minggao LiangDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-4451-0921
Ahmad MalikCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Judy PawlingCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0003-3759-8555
Silvana B De LorenzoDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Asma AliDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Paul A DeckerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-3756-4227
Matt L KoselDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Arijit PandaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-5156-6459
Khalid N Al-ZahraniCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-5771-7537
Lingyan JiangCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Jared W L BrowningDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0001-9938-7193
Chris LowdenCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-1839-164X
Michael GeuenichCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
J Javier HernandezCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-6735-4303
Jessica T GosioCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Musaddeque AhmedHospital for Sick Children, Toronto, ON M5G 1X8, Canada.ORCID 0000-0002-5076-1102
Sampath Kumar LoganathanCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-8809-1466
Jacob BermanCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-6454-4996
Daniel TrckaCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-2196-7160
Kulandaimanuvel Antony MichealrajHospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Jerome FortinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Brittany CarsonCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Ethan W HollingsworthDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.ORCID 0000-0002-5188-3929
Sandra JacintoDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.
Parisa MazrooeiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Lily ZhouPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Andrew EliaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.ORCID 0000-0001-8619-1415
Mathieu LupienPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.ORCID 0000-0003-0929-9478
Housheng Hansen HePrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.ORCID 0000-0003-2898-3363
Daniel J MurphyInstitute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, Scotland, UK.
Liguo WangDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2072-4826
Alexej AbyzovDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-5405-6729
James W DennisCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-0295-5877
Philipp G MaassDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-2742-8301
Kieran CampbellCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Michael D WilsonDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-4015-3066
Daniel H LachanceDepartments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Margaret WrenschDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-3070-7600
John WienckeDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
Tak MakPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.ORCID 0000-0001-6766-861X
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.ORCID 0000-0002-8748-3732
Diane E DickelEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.ORCID 0000-0001-5497-6824
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.ORCID 0000-0002-4130-7784
Jeffrey WranaCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0003-0932-0644
Michael D TaylorHospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Gelareh ZadehHospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Peter DirksDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0001-5718-6465
Jeanette E Eckel-PassowDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-6113-1114
Liliana AttisanoDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0003-4824-2642
Ana PomboMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany.ORCID 0000-0002-7493-6288
Cristiane M IdaDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2768-2913
Evgeny Z KvonDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.ORCID 0000-0002-1562-0945
Robert B JenkinsDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4049-694X
Daniel SchramekCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-9977-2104
Mount Sinai Hospital · CAMayo Clinic · USUniversity of Toronto · CAMayo Clinic in Florida · USUniversity Health Network · CAHospital for Sick Children · CALawrence Berkeley National Laboratory · USUniversity of California, Irvine · USMax Delbrück Center · DEUniversity of California, San Francisco · USCancer Research UK Scotland Institute · GBOntario Institute for Cancer Research · CA
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3MTissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4MGeneration of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1MTargeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5MGENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5MInternational Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0MGenetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9MImmune epigenetic biomarkers of survival in glioma epidemiologyR01CA207360 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2017 to 2021
$3.8MUNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMASR01CA230712 · NCI · MAYO CLINIC ROCHESTER · PI JENKINS, ROBERT B. · 2018 to 2022
$3.3MTraining Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3MDetection of somatic, subclonal and mosaic CNVs from sequencingU24CA220242 · NCI · MAYO CLINIC ROCHESTER · PI ABYZOV, ALEXEJ · 2018 to 2022
$2.6MDeciphering the mechanism of long-range gene regulation in vivoDP2GM149555 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KVON, EVGENY · 2022 to 2025
$2.4MCancer Research UK 27603NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA108961NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA119215NCI NIH HHS R01 CA139020NCI NIH HHS R01 CA207360NCI NIH HHS R01 CA230712NCI NIH HHS U24 CA220242NHGRI NIH HHS R00 HG009682NHGRI NIH HHS R01 HG003988NIGMS NIH HHS DP2 GM149555NINDS NIH HHS T32 NS082174
Abstract
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase (
Indexed as
Brain NeoplasmsChromosomes, Human, Pair 8GliomaIsocitrate DehydrogenaseAnimalsHumansMiceMutationPolymorphism, Single NucleotideIDH1 protein, humanIsocitrate Dehydrogenase
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