ArticlePloS one2022
A GC-MC analysis of chemical compounds and identification of the antibacterial characteristics of the essential oil of two species exclusive to Iranian habitats: New chemotypes.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 11 citations in OpenAlex.
- GC-MS characterization and in vitro antimicrobial activity of essential oils from selected Lamiaceae species collected in Kashan, Iran.BMC plant biology · 2026Article
- Essential oil and extract of clevenger's waste of hymenocrater calycinus (boiss.) benth. as a non-toxicity option for cutaneous burns according to traditional use.Scientific reports · 2026Article
- Essential Oil from the Leaves of the Dwarf Cashew Tree (Foods (Basel, Switzerland) · 2025Article
- Gas Chromatography/Mass Spectrometry Chemical Profiling of Volatile Compounds from Cranberry Plant Byproducts as Potential Antibacterials, Antifungals, and Antioxidants.Molecules (Basel, Switzerland) · 2025Article
- Chemical composition and antimicrobial activity of a newly identified chemotype of Achillea wilhelmsii K.Koch from Kashan, Iran.Scientific reports · 2024Article
- Evaluation of Yield, Chemical Profile, and Antimicrobial Activity of Teucrium polium L. Essential Oil Used in Iranian Folk Medicine.Applied biochemistry and biotechnology · 2024Article
- Phytochemical investigation of the n-hexane-extracted oil from four umbelliferous vegetables using GC/MS analysis in the context of antibacterial activity.Scientific reports · 2024Article
- Article
- Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects ofMolecules (Basel, Switzerland) · 2022Article
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Abstract
backgroundThe diversity found in the chemical compounds of a single species in different regions results in different biologic characteristics which can be considered as a strong source for identifying new chemotypes. Hymenocrater incanus Bunge and Dracocephalum kotschyi Boiss. are exclusive species of the Lamiaceae family which grow in the western and central habitats of Iran. This study was designed and carried out to determine the yield, identify the chemical compounds, and evaluate the antimicrobial characteristics of the essential oil (EO) of these two species in Iran for the first time.
methodsThe flowering twigs of the species D. kotschyi and H. incanus were collected from the villages of Totmach and Kamu in Isfahan province respectively, in May 2019. The EO of these plants was extracted and separated using the water distillation method, utilizing the Clevenger device. The EO compounds were analyzed using a gas chromatograph coupled with a mass spectrometer (GC-MS). The evaluation of antimicrobial characteristics was carried out by determining the growth inhibition zone implementing the Agar method, the minimum inhibition concentration (MIC), and the minimum bactericidal/fungicidal concentration (MFC/MBC) utilizing liquid dilution culture.
resultsThe results indicated that the highest yield belonged to the EO of D. kotschyi at %2.6 (w/w). In this EO there were citral (%25.44), neral (%20.87), α-pinene (%14.48), trans-geranic acid methyl ester (%9.74), and D-limonene (%6.87). Moreover, H. incanus had the dominant compounds (-)-Spathulenol (%12.61), caryophyllene (%10.00), linolenic acid (%8.54), 1,8-cineole (%5.95), palmitic acid (%5.35), and α-cadinol (%5.17). The largest diameter of growth inhibition zone belonged to the H. incanus EO against the Gram-positive bacteria S. pyogenes (~17.67mm). The strongest inhibition activities in the form of growth inhibition diameter exhibited by the D. kotschyi EO were against the Gram-negative bacteria S. paratyphi-A serotype (~ 12 mm), K. pneumoniae, and Sh. dysenteriae (~ 11 mm) which was significant compared to the Gram-positive rifampin (~ 8 mm).
conclusionsIt can be seen that these species are new chemotypes with special and novel chemical compounds which can potentially be used to manufacture natural antibiotics against some bacterial strains.
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