Evidence map›Paper›PMID 36201539›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts.

Martina Sassone-Corsi, Shalhevet Azriel, Ariel Simon, Deepshika Ramanan, Adriana Ortiz-Lopez, Felicia Chen, Nissan Yissachar, Diane Mathis, Christophe Benoist

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Review
  7. Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Martina Sassone-CorsiDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Shalhevet AzrielGoodman Faculty of Life Sciences, Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Ariel SimonGoodman Faculty of Life Sciences, Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Deepshika RamananDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Adriana Ortiz-LopezDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Felicia ChenDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Nissan YissacharGoodman Faculty of Life Sciences, Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Harvard University · USBar-Ilan University · IL

Funding

Treg cell diversity and homeostatic controlR01AI150686 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2020 to 2024
$2.6M
T regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI125603HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI150686NIAID NIH HHS R01 AI125603NIAID NIH HHS R01 AI150686
6 · The paper itself

Abstract

T cells that express the transcription factor RORγ, regulatory (Treg), or conventional (Th17) are strongly influenced by intestinal symbionts. In a genetic approach to identify mechanisms underlying this influence, we performed a screen for microbial genes implicated, in germfree mice monocolonized with

Indexed as

Gastrointestinal TractNuclear Receptor Subfamily 1, Group F, Member 3T-Lymphocytes, RegulatoryAnimalsEscherichia coliImmunoglobulin ALymphocyte ActivationMiceMyeloid CellsTranscription FactorsImmunoglobulin ANuclear Receptor Subfamily 1, Group F, Member 3Transcription FactorscapsuleCD4+ T cellgenetic screengutIgA

Identifiers

PMID36201539
PMCPMC9565271
OpenAlexW4302363605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.