ArticlePloS one2022
Spatiotemporal distribution analysis of syphilis in Brazil: Cases of congenital and syphilis in pregnant women from 2001-2017.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 31 citations in OpenAlex.
- Analysis of the spatio-temporal pattern and evolutionary trends of syphilis at township level in Xining City, Qinghai Province, China from 2008 to 2024.Scientific reports · 2026Article
- Hospitalizations for congenital infections in Brazil's unified health system: nationwide trends and regional disparities, 2008-2024.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Spatial analysis of mortality due to congenital syphilis in Brazil from 2008 to 2022.PloS one · 2026Article
- Spatio-temporal modeling of congenital syphilis: a 15-year ecological and population-based study.BMC pediatrics · 2025Article
- Advancing syphilis diagnosis: multi-phase study evaluation of a TpN17-based double-antigen sandwich ELISA for detectingFrontiers in microbiology · 2025Article
- Historical Trends and Epidemiological Indicators of Congenital Syphilis in São Paulo, Brazil: 1986-2023.Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
- Gaps in the prevention of mother-to-child transmission of syphilis: a review of reported cases, South Africa, January 2020-June 2022.Journal of tropical pediatrics · 2024Article
- Associated factors, incidence, and management of gestational and congenital syphilis in a Brazilian state capital: a cross-sectional study.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Hospitalizations for congenital syphilis in children under one year old in the state of Pará, Brazilian Amazon: ecological study.BMC pediatrics · 2023Article
- Estimating the real burden of gestational syphilis in Brazil, 2007-2018: a Bayesian modeling study.Lancet regional health. Americas · 2023Article
- Congenital syphilis in Switzerland: a marker of inequality? A mini-review.Frontiers in public health · 2023Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Brazil, the notification of congenital (CS) and syphilis in pregnant women (SiP) is compulsory. Notification data provided by the Ministry of Health in combination with the mapping of vulnerable geographic areas is essential to forecasting possible outbreaks and more effectively combating infection through monitoring. We aim to evaluate the spatiotemporal distribution and epidemiological aspects of reported cases of CS and SiP in Brazil. A retrospective ecological study was carried out using secondary surveillance data obtained from the Brazilian National Notifiable Diseases Information System (SINAN) database, considering all reported cases of CS and SiP between 2001 to 2017. Epidemiological characteristics and time trends were analyzed using joinpoint regression models and spatial distribution, considering microregions or states/macroregions as units of analysis. A total of 188,630 (359/100,000 birth lives) CS and 235,895 of SiP (6.3/100,000 inhabitants) were reported during the period studied. In general, the epidemiologic profile of Brazil indicates most reported CS cases occurred in "mixed-race" newborns who were diagnosed within seven days of birth and whose mothers had received prenatal care, but the epidemiologic profile varies by Brazilian macroregion. Regarding SiP, most cases were among women who self-reported 'mixed-race', were aged 20-39 years, had up to eight years of formal education and were diagnosed with primary or latent syphilis. Approximately 549 (98.4%) and 558 (100%) microregions reported at least one case of CS and SiP, respectively. From 2012 to 2016, CS cases increased significantly in almost all Brazilian states, most notably in the South, Southeast, and Central-West macroregions, from 2001-2017 and the relative risk (RR) of SiP increased around 400% (RR: 1,00 to 445,50). Considering the epidemiological scenario of the infection in Brazil, it is necessary to enhance preventive, control and eradication measures.
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