Evidence map›Paper›PMID 36201485›Full record

ArticlePloS one2022

Hydrothermal assisted biogenic synthesis of silver nanoparticles: A potential study on virulent candida isolates from COVID-19 patients.

Fatma O Khalil, Muhammad B Taj, Enas M Ghonaim, Shimaa Abed El-Sattar, Sally W Elkhadry, Hala El-Refai, Omar M Ali, Ahmed Salah A Elgawad, Heba Alshater

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Fatma O KhalilClinical and Molecular Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.ORCID 0000-0002-3157-5232
Muhammad B TajDivision of Inorganic Chemistry, Institute of Chemistry, The Islamia University Bahawalpur, Bahawalpur, Pakistan.ORCID 0000-0001-5343-6893
Enas M GhonaimClinical and Molecular Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Shimaa Abed El-SattarClinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Sally W ElkhadryEpidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Hala El-RefaiClinical and Molecular Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Omar M AliDepartment of Chemistry, Turabah University College, Turabah Branch, Taif University, Taif Saudi Arabia.ORCID 0000-0002-2653-1542
Ahmed Salah A ElgawadDepartment of Clinical Pathology, National Liver Institute, Menoufia University Hospital, Menoufia University, Shebin El-Kom, Egypt.
Heba AlshaterDepartment of Forensic Medicine and Clinical Toxicology, Menoufia University Hospital, Menoufia University, Shebin El-Kom, Egypt.
Menoufia University · EGIslamia University of Bahawalpur · PKTaif University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Till now the exact mechanism and effect of biogenic silver nanoparticles on fungus is an indefinable question. To focus on this issue, the first time we prepared hydrothermal assisted thyme coated silver nanoparticles (T/AgNPs) and their toxic effect on Candida isolates were determined. The role of thyme (Thymus Vulgaris) in the reduction of silver ions and stabilization of T/AgNPs was estimated by Fourier transforms infrared spectroscopy, structure and size of present silver nanoparticles were detected via atomic force microscopy as well as high-resolution transmission electron microscopy. The biological activity of T/AgNPs was observed against Candida isolates from COVID-19 Patients. Testing of virulence of Candida species using Multiplex PCR. T/AgNPs proved highly effective against Candida albicans, Candida kruzei, Candida glabrata and MIC values ranging from 156.25 to 1,250 μg/mL and MFC values ranging from 312.5 to 5,000 μg/mL. The structural and morphological modifications due to T/AgNPs on Candida albicans were detected by TEM. It was highly observed that when Candida albicans cells were subjected to 50 and 100 μg/mL T/AgNPs, a remarkable change in the cell wall and cell membrane was observed.

Indexed as

COVID-19Metal NanoparticlesAnti-Bacterial AgentsAntifungal AgentsCandidaCandida albicansHumansMicrobial Sensitivity TestsSilverAnti-Bacterial AgentsAntifungal AgentsSilver

Identifiers

PMID36201485
PMCPMC9536612
OpenAlexW4302363602

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.