Evidence map›Paper›PMID 36201439›Full record

ArticleThe Journal of comparative neurology2023

Subclass-specific expression patterns of MET receptor tyrosine kinase during development in medial prefrontal and visual cortices.

Alexandra L Lanjewar, Sonum Jagetia, Zuhayr M Khan, Kathie L Eagleson, Pat Levitt

Open access · hybridAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Developmental and molecular contributions to contextual fear memory emergence in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alexandra L LanjewarProgram in Developmental Neuroscience and Neurogenetics, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA.ORCID 0000-0002-2037-0717
Sonum JagetiaProgram in Developmental Neuroscience and Neurogenetics, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA.
Zuhayr M KhanProgram in Developmental Neuroscience and Neurogenetics, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA.
Kathie L EaglesonProgram in Developmental Neuroscience and Neurogenetics, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA.
Pat LevittProgram in Developmental Neuroscience and Neurogenetics, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA.
University of Southern California · US

Funding

Function &Structure Adaptation in Forebrain DevelopmentR01MH067842 · NIMH · VANDERBILT UNIVERSITY · PI LEVITT, PAT · 2002 to 2023
$10.8M
Function and Structure Adaptations in Forebrain DevelopmentR56MH067842 · NIMH · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEVITT, PAT · 2014 to 2014
$662k
NIMH NIH HHS R01 MH067842NIMH NIH HHS R56 MH067842
6 · The paper itself

Abstract

Met encodes a receptor tyrosine kinase (MET) that is expressed during development and regulates cortical synapse maturation. Conditional deletion of Met in the nervous system during embryonic development leads to deficits in adult contextual fear learning, a medial prefrontal cortex (mPFC)-dependent cognitive task. MET also regulates the timing of critical period plasticity for ocular dominance in primary visual cortex (V1). However, the underlying circuitry responsible remains unknown. Therefore, this study determines the broad expression patterns of MET throughout postnatal development in mPFC and V1 projection neurons (PNs), providing insight into similarities and differences in the neuronal subtypes and temporal patterns of MET expression between cortical areas. Using a transgenic mouse line that expresses green fluorescent protein (GFP) in Met

Indexed as

Proto-Oncogene Proteins c-metVisual CortexAnimalsFearFemaleMiceMice, TransgenicNeuronsPrefrontal CortexPregnancyProto-Oncogene Proteins c-metcortico-corticalMET receptor tyrosine kinasemolecular heterogeneityneuronal subclassesprojection neuronssubcerebral

Identifiers

PMID36201439
PMCPMC9691614
OpenAlexW4302762753

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.