Evidence map›Paper›PMID 36201358›Full record

ArticleChemical research in toxicology2022

Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures.

Matthew M Behymer, Huaping Mo, Naoaki Fujii, Vallabh Suresh, Adriano Chan, Jangweon Lee, Anjali K Nath, Kusumika Saha, Sari B Mahon, Matthew Brenner and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Matthew M BehymerDepartment of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana47907, United States.
Huaping MoDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana47907, United States.
Naoaki FujiiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana47907, United States.
Vallabh SureshDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana47907, United States.
Adriano ChanDepartment of Medicine, University of California, San Diego, California92093, United States.
Jangweon LeeBeckman Laser Institute and Medical Clinic, Department of Medicine, University of California, Irvine, California92697, United States.
Anjali K NathDepartment of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts02115, United States.
Kusumika SahaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts02115, United States.
Sari B MahonBeckman Laser Institute and Medical Clinic, Department of Medicine, University of California, Irvine, California92697, United States.
Matthew BrennerBeckman Laser Institute and Medical Clinic, Department of Medicine, University of California, Irvine, California92697, United States.
Calum A MacRaeDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts02115, United States.
Randall PetersonDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah84112, United States.ORCID 0000-0003-0727-3469
Gerry R BossDepartment of Medicine, University of California, San Diego, California92093, United States.
Gregory T KnippDepartment of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana47907, United States.
Vincent Jo DavissonDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana47907, United States.ORCID 0000-0003-1182-0007
Purdue University West Lafayette · USUniversity of California, Irvine · USBrigham and Women's Hospital · USUniversity of California San Diego · USBeth Israel Deaconess Medical Center · USUniversity of Utah · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Training & Education CoreU54NS112107 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MACRAE, CALUM A., PETERSON, RANDALL T · 2019 to 2023
$16.0M
NCI NIH HHS P30 CA023168NINDS NIH HHS U54 NS112107
6 · The paper itself

Abstract

The development of rapidly acting cyanide countermeasures using intramuscular injection (IM) represents an unmet medical need to mitigate toxicant exposures in mass casualty settings. Previous work established that cisplatin and other platinum(II) or platinum(IV)-based agents effectively mitigate cyanide toxicity in zebrafish. Cyanide's

Indexed as

Antineoplastic AgentsPlatinumAnimalsCyanidesDimethyl SulfoxideLigandsMiceRabbitsSulfidesZebrafishAntineoplastic AgentsCyanidesDimethyl SulfoxideLigandsPlatinumSulfides

Identifiers

PMID36201358
PMCPMC9682522
OpenAlexW4302362231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.