Evidence map›Paper›PMID 36201326›Full record

ArticleAmerican journal of physiology. Renal physiology2022

NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel.

Elena Mironova, Crystal R Archer, Aleksandr E Vendrov, Marschall S Runge, Nageswara R Madamanchi, William J Arendshorst, James D Stockand, Tarek Mohamed Abd El-Aziz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Elena MironovaDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Crystal R ArcherDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Aleksandr E VendrovDepartment of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-4971-8040
Marschall S RungeDepartment of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-6665-4029
Nageswara R MadamanchiDepartment of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-0590-0908
William J ArendshorstDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
James D StockandDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.ORCID 0000-0002-3817-4319
Tarek Mohamed Abd El-AzizDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.ORCID 0000-0002-3441-9673
The University of Texas Health Science Center at San Antonio · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · US

Funding

Nox1/NoxA1 Regulation of Vascular Reactivity and Sodium Excretion in Health and Hypertension.R01HL139842 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARENDSHORST, WILLIAM J, MADAMANCHI, NAGESWARA R · 2018 to 2021
$2.9M
NHLBI NIH HHS R01 HL139842
6 · The paper itself

Abstract

The activity of the epithelial Na

Indexed as

Angiotensin IIEpithelial Sodium ChannelsAdaptor Proteins, Signal TransducingAnimalsMiceMice, KnockoutNADPH Oxidase 1NADPH OxidasesSodiumAdaptor Proteins, Signal TransducingAngiotensin IIEpithelial Sodium ChannelsNADPH Oxidase 1NADPH OxidasesNoxa1 protein, mouseSodiumcollecting ducthypertensionreactive oxygen speciesrenal physiologysodium excretion

Identifiers

PMID36201326
PMCPMC9705023
OpenAlexW4302362443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.