Evidence map›Paper›PMID 36201241›Full record

ArticleeLife2022

Fat body phospholipid state dictates hunger-driven feeding behavior.

Kevin P Kelly, Mroj Alassaf, Camille E Sullivan, Ava E Brent, Zachary H Goldberg, Michelle E Poling, Julien Dubrulle, Akhila Rajan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Advances in Adipose Tissue Biology.Endocrine reviews · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Self-DNA Inhibition inBiology · 2023
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kevin P Kelly *Basic Sciences Division, Fred Hutch, Seattle, United States.ORCID 0000-0002-8632-2339
Mroj Alassaf *Basic Sciences Division, Fred Hutch, Seattle, United States.ORCID 0000-0001-6277-9417
Camille E SullivanBasic Sciences Division, Fred Hutch, Seattle, United States.
Ava E BrentBasic Sciences Division, Fred Hutch, Seattle, United States.
Zachary H GoldbergBasic Sciences Division, Fred Hutch, Seattle, United States.ORCID 0000-0003-2972-9682
Michelle E PolingBasic Sciences Division, Fred Hutch, Seattle, United States.
Julien DubrulleCellular Imaging Core, Shared Resources, Fred Hutch, Seattle, United States.ORCID 0000-0002-4186-7749
Akhila RajanBasic Sciences Division, Fred Hutch, Seattle, United States.ORCID 0000-0003-1160-5796
Fred Hutch Cancer Center · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Chromosome Metabolism and Cancer Training GrantT32CA009657 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 1991 to 2020
$7.6M
Functional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2019 to 2023
$6.8M
Investigating How Cellular Mechanisms Interface To Maintain Energy BalanceR35GM124593 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Akhila Rajan · 2017 to 2026
$4.5M
NCI NIH HHS T32 CA009657NIGMS NIH HHS P41 GM132087NIGMS NIH HHS R01 GM084947NIGMS NIH HHS R35 GM124593NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

Diet-induced obesity leads to dysfunctional feeding behavior. However, the precise molecular nodes underlying diet-induced feeding motivation dysregulation are poorly understood. The fruit fly is a simple genetic model system yet displays significant evolutionary conservation to mammalian nutrient sensing and energy balance. Using a longitudinal high-sugar regime in

Indexed as

Drosophila melanogasterHungerAnimalsDrosophilaFat BodyFeeding BehaviorHumansMammalsObesityPhosphatidylethanolaminesPhospholipidsSugarsPhosphatidylethanolaminesPhospholipidsSugarsapolipoproteinsD. melanogasterDrosophilageneticsgenomicshomeostasisinsulin resistanceobesityPECT

Identifiers

PMID36201241
PMCPMC9566863
OpenAlexW4302362788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.