Evidence map›Paper›PMID 36201049›Full record

ReviewCell and tissue research2023

Emergence of CWD strains.

Alicia Otero, Camilo Duque Velasquez, Debbie McKenzie, Judd Aiken

Open access · hybridAbstract readReview
In one paragraph

Review in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  17. Adaptation of the protein misfolding cyclic amplification (PMCA) technique for the screening of anti-prion compounds.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  18. Article
  19. Article
  20. New developments in prion disease research.Cell and tissue research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alicia OteroCentro de Encefalopatias y Enfermedades Transmisibles Emergentes, University of Zaragoza, 50013, Zaragoza, Spain.
Camilo Duque VelasquezDepartment of Biological Science, University of Alberta, Edmonton, AB, Canada.
Debbie McKenzieDepartment of Biological Science, University of Alberta, Edmonton, AB, Canada. debbie.mckenzie@ualberta.ca.ORCID http://orcid.org/0000-0002-9291-6977
Judd AikenCentre for Prions and Protein Folding Diseases, Brain and Aging Research Building, University of Alberta, Edmonton, AB, T6G 2M8, Canada. judd.aiken@ualberta.ca.
University of Alberta · CAUniversidad de Zaragoza · ES

Funding

Agriculture Funding Consortium RDAR 2022N067RGenome Canada LSARP 10205
6 · The paper itself

Abstract

Chronic wasting disease (CWD) strains present a novel challenge to defining and mitigating this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other prion diseases (bovine spongiform encephalopathy, sheep scrapie), CWD strains can affect biochemical and neuropathological properties of the infectious agent, and importantly interspecies transmission. To date, ten CWD strains have been characterized. The expanding range of CWD in North America and its presence in South Korea as well as Scandinavian countries will potentially result in millions of cervids infected with CWD; thus, novel strains will continue to emerge. In this review, we will summarize the characteristics of known CWD strains and describe the impact of prion protein gene polymorphisms on the generation of strains. We will also discuss the evidence that individual cervids can harbor more than one CWD strain, complicating strain analysis, and affecting selection and adaptation of strains in new hosts.

Indexed as

DeerPrionsWasting Disease, ChronicAnimalsCattlePrion ProteinsSheepPrion ProteinsPrionsChronic wasting diseasePrion strainsPrP structure

Identifiers

PMID36201049
PMCPMC10113326
OpenAlexW4302283343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.