ArticleArchives of dermatological research2023
Effect of platelet-rich fibrin (PRF) membranes on the healing of infected skin wounds.
Article in Archives of dermatological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Enhancing Regenerative Outcomes: Histopathological Comparison of Calcium Hydroxylapatite Alone and Combined With Platelet-rich Fibrin: A 6-week Study.Plastic and reconstructive surgery. Global open · 2026Article
- Enhancing Regenerative Outcomes: Histological Comparison of Hydroxyapatite-Carboxymethylcellulose Combined With Saline vs Platelet-rich Fibrin: A 21-day Study.Plastic and reconstructive surgery. Global open · 2026Article
- Fibrin-Based Biomaterials in Wound Healing and Soft Tissue Regeneration: Biological Mechanisms and Clinical Applications.Gels (Basel, Switzerland) · 2026Review
- Therapeutic Effect of Photobiomodulation and Single Intratendinous Injection at the Lesion Site of Platelet-Rich Fibrin in Inducted Tendinopathy.Journal of biophotonics · 2026Article
- The Potential of Menstrual Blood-Derived Extracellular Vesicles (MenMSC-Evs) in Combination with Platelet-Rich Fibrin (PRF) as a Biological Adjuvant for Improving Full-Thickness Wound Healing.Stem cell reviews and reports · 2026Article
- Antimicrobial Peptides for Skin Wound Healing.Biomolecules · 2025Review
- Evaluation of enamel matrix derivative used alone or added to collagen membrane for tissue repair: in vivo animal study using a rat dorsal wound model.International journal of implant dentistry · 2025Article
- Diagnostic and Clinical Outcomes of Three Regenerative Strategies for Alveolar Bone Defects: A Comparative Study Using CBCT and ISQ.Diagnostics (Basel, Switzerland) · 2025Article
- Innate immunity and wound repair: The platelet-rich fibrin advantage.World journal of biological chemistry · 2025Article
- Evaluation of the effects of smoking on the clinical and histological characteristics and levels of growth factors in autologous fibrin membranes.Oral and maxillofacial surgery · 2025Article
- Lyophilized horizontal platelet rich fibrin promotes the healing of infected burns/wounds by modulating macrophage polarization and fibroblast migration.Frontiers in bioengineering and biotechnology · 2025Article
- Advanced platelet-rich fibrin promotes healing of induced corneal ulcer in donkeys (Equus asinus).Scientific reports · 2023Article
- Standardization of Animal Models and Techniques for Platelet-Rich Fibrin Production: A Narrative Review and Guideline.Bioengineering (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering focuses on wound healing and tissue regeneration. Platelet-rich fibrin (PRF) is a fibrin matrix containing cytokines, growth factors and cells that are gradually released into the wound over time. This study aimed to evaluate the effect of PRF membranes on wound repair and microbial control in infected wounds. Skin wounds were performed on the dorsum of rats using a 6 mm diameter metal punch. The defects were randomly assigned into four groups (n = 12/each) accordingly to the treatment: G1, noninfected wound filled only with clot; G2, noninfected wound with PRF; G3, infected wound (S. aureus) without PRF; G4, infected wound (S. aureus) with PRF. After 7 and 14 days, macroscopic and histological analyses of the wounds were performed. Furthermore, the quantification of β-defensin in PRF was measured by ELISA. At 14 days, the groups with PRF (G2 and G4) had wound sizes significantly smaller than the original defects (6 mm) (p < 0.05) and significantly smaller than those not treated with PRF, in both the infected and noninfected groups (p < 0.05). Furthermore, the groups with infected wounds (G3 and G4) demonstrated a significantly lower inflammation score in the PRF group than in the noninfected groups (p < 0.05). In vitro analysis of β-defensin was performed in all PRF membrane groups, and the median value was 1.444 pg/mL. PRF in the wounds of both control and infected rats played an important role in the modulation of tissue healing, most notably in infected sites.
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