ArticlePediatric cardiology2023
The Relationship Between Placental Pathology and Neurodevelopmental Outcomes in Complex Congenital Heart Disease.
Article in Pediatric cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Diminished Late Gestation Placental Volume in Fetal Heart Disease and Implications for Birth Anthropometrics.Journal of cardiovascular development and disease · 2026Article
- Charting normative reference values and Z-scores for MRI-derived in vivo placental growth.Pediatric radiology · 2026Observational
- Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality.Early human development · 2026Article
- Placental Inflammation in Preterm Premature Rupture of Membranes and Risk of Neurodevelopmental Disorders.Cells · 2025Review
- Placental and Fetal In Utero Growth Among Fetuses With Congenital Heart Disease.JAMA network open · 2025Article
- School Readiness in Preschool-Age Children with Critical Congenital Heart Disease.Pediatric cardiology · 2025Article
- Congenital Heart Disease Fetuses Have Decreased Mid-Gestational Placental Flow, Placental Malperfusion Defects, and Impaired Growth.JACC. Advances · 2025Article
- Physically active pregnancies: Insights from the placenta.Physiological reports · 2024Review
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Scientific reports · 2024Article
- Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Placenta-Heart-Brain Connection in Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Research square · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex congenital heart disease (CCHD) is associated with impaired neurodevelopmental outcomes. Peri- and post-operative factors are known contributors while the impact of the prenatal environment is not yet delineated. Variations in fetal circulation, seen in transposition of the great arteries (TGA) and single ventricular physiology (SVP), are associated with placenta abnormalities. These abnormalities may be associated with placental insufficiency, a risk factor for poor neurodevelopmental outcomes. We hypothesized there is a correlation between placental pathology and impaired neurodevelopmental outcomes in patients with CCHD. We performed a single center retrospective cohort study with patients with TGA and SVP from 2010 to 2017 at Children's Wisconsin. Patient variables were obtained from the medical record. Bayley Scales of Infant Development Third Edition standard scores for cognitive, motor, and language performance were collected from neurodevelopmental visits. Placenta pathology reports were reviewed with tabulation of predetermined anatomical and pathological characteristics. We identified 79 patients in our cohort and 61 (77.2%) had abnormal placentas. There was no significant difference between the two groups in any demographic or clinical variables. For cognitive and motor performance, without adjusting for the covariates, infants with placental abnormalities had significantly lower scores compared to infants without (p = 0.026, p = 0.045 respectively). Conversely, there was no significant difference in language scores between the two groups (p = 0.12). Placenta abnormalities are common in patients with CCHD, and placenta abnormalities are associated with impaired neurodevelopmental outcomes. These results underscore the complex causal pathways of neurodevelopmental impairment in infants with CCHD and offer opportunities for targeted postnatal developmental interventions after discharge.
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