ArticleSchizophrenia bulletin2023
Cerebellar Functional Dysconnectivity in Drug-Naïve Patients With First-Episode Schizophrenia.
Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods.Frontiers in psychiatry · 2022Pooled it
- Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.Neuroscience bulletin · 2026Article
- Ketamine attenuates anxiety-like behavior and oxidative imbalance in the maternal immune activation model: emphasis on the cerebellum.Psychopharmacology · 2026Article
- Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia.Cerebellum (London, England) · 2026Article
- Cerebellar-Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits.Schizophrenia bulletin · 2026Article
- Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis.Schizophrenia bulletin · 2025Article
- Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia.Research square · 2025Article
- Unravelling the genetic and molecular basis of low-frequency rTMS induced changes in functional connectivity density in schizophrenia patients with auditory verbal hallucinations.Translational psychiatry · 2025Article
- Abnormal eye movement, brain regional homogeneity in schizophrenia and clinical high-risk individuals and their associated gene expression profiles.Schizophrenia (Heidelberg, Germany) · 2025Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- The immediate alteration of cerebellar Glx/GABA and cerebello-thalamo-cortical connectivity in patients with schizophrenia after cerebellar TMS.Schizophrenia (Heidelberg, Germany) · 2025Article
- Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia.Frontiers in psychiatry · 2025Article
- Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables.Schizophrenia bulletin · 2024Article
- A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis.The American journal of psychiatry · 2023Article
- Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia.Schizophrenia bulletin · 2023Article
- Editorial: Cerebellar structure and function in psychotic disorders: from mechanisms to clinics.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebellar functional dysconnectivity has long been implicated in schizophrenia. However, the detailed dysconnectivity pattern and its underlying biological mechanisms have not been well-charted. This study aimed to conduct an in-depth characterization of cerebellar dysconnectivity maps in early schizophrenia. STUDY
designResting-state fMRI data were processed from 196 drug-naïve patients with first-episode schizophrenia and 167 demographically matched healthy controls. The cerebellum was parcellated into nine functional systems based on a state-of-the-art atlas, and seed-based connectivity for each cerebellar system was examined. The observed connectivity alterations were further associated with schizophrenia risk gene expressions using data from the Allen Human Brain Atlas. STUDY
resultsOverall, we observed significantly increased cerebellar connectivity with the sensorimotor cortex, default-mode regions, ventral part of visual cortex, insula, and striatum. In contrast, decreased connectivity was shown chiefly within the cerebellum, and between the cerebellum and the lateral prefrontal cortex, temporal lobe, and dorsal visual areas. Such dysconnectivity pattern was statistically similar across seeds, with no significant group by seed interactions identified. Moreover, connectivity strengths of hypoconnected but not hyperconnected regions were significantly correlated with schizophrenia risk gene expressions, suggesting potential genetic underpinnings for the observed hypoconnectivity.
conclusionsThese findings suggest a common bidirectional dysconnectivity pattern across different cerebellar subsystems, and imply that such bidirectional alterations may relate to different biological mechanisms.
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