Evidence map›Paper›PMID 36200871›Full record

ArticleMolecular biology of the cell2022

Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis.

Abhishek Poddar, Yen-Yu Hsu, Faith Zhang, Abeda Shamma, Zachary Kreais, Clare Muller, Mamata Malla, Aniruddha Ray, Allen P Liu, Qian Chen

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Regulation of Yeast Cytokinesis by Calcium.Journal of fungi (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Calcium-triggered DNA-mediated membrane fusion in synthetic cells.Chemical communications (Cambridge, England) · 2023
    Article
  10. Article
  11. Calcium-triggered DNA-mediated membrane fusion in synthetic cells.bioRxiv : the preprint server for biology · 2023
    Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Abhishek PoddarDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606.
Yen-Yu HsuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109.
Faith ZhangDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606.
Abeda ShammaDepartment of Physics and Astronomy, University of Toledo, Toledo, OH 43606.
Zachary KreaisDepartment of Physics and Astronomy, University of Toledo, Toledo, OH 43606.
Clare MullerDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606.
Mamata MallaDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606.
Aniruddha RayDepartment of Physics and Astronomy, University of Toledo, Toledo, OH 43606.
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109.
Qian ChenDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606.ORCID 0000-0002-2768-6570
University of Toledo · USUniversity of Michigan · US

Funding

The mechanism of cell size regulation by polycystinsR01GM144652 · NIGMS · UNIVERSITY OF TOLEDO · PI Qian Chen · 2022 to 2026
$1.6M
Development of a mechanosensitive synthetic cell for mediating intercellular communication - Diversity SupplementR01EB030031 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, ALLEN PO-CHIH · 2020 to 2024
$1.3M
The molecular roles of polycystin in cytokinesisR15GM134496 · NIGMS · UNIVERSITY OF TOLEDO · PI CHEN, QIAN · 2019 to 2019
$444k
6 · The paper itself

Abstract

Pkd2 is the fission yeast homologue of polycystins. This putative ion channel localizes to the plasma membrane. It is required for the expansion of cell volume during interphase growth and cytokinesis, the last step of cell division. However, the channel activity of Pkd2 remains untested. Here, we examined the calcium permeability and mechanosensitivity of Pkd2 through in vitro reconstitution and calcium imaging of

Indexed as

CalciumSchizosaccharomycesSchizosaccharomyces pombe ProteinsTRPP Cation ChannelsCalcium SignalingCytokinesisPermeabilityCalciumSchizosaccharomyces pombe ProteinsTRPP Cation Channels

Identifiers

PMID36200871
PMCPMC9727806
OpenAlexW4302304542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.